ternary fungicidal composition, its preparation process, method to control one or more harmful micro

专利摘要:
TERNARY FUNGICID MIXTURES. The present invention relates to new mixtures, to processes for the preparation of these compounds, to compositions that include these mixtures and to their use as biologically active compounds, mainly for the control of dangerous microorganisms in the protection of cultures and the protection of materials and to increase plant health.
公开号:BR112015012055B1
申请号:R112015012055-5
申请日:2013-11-25
公开日:2021-01-12
发明作者:Peter Dahmen；Heiko Rieck；Christophe Dubost
申请人:Bayer Cropscience Ag；
IPC主号:

专利说明:

[0001] The present invention relates to new mixtures, to a process for the preparation of these mixtures, to compositions comprising these mixtures and to their use as biologically active mixtures, in particular in the control of pathogenic microorganisms in crop protection and protecting materials and improving plant health.
[0002] Carboxamides of the General Formula
, in which - R1 represents a hydrogen atom or a methyl group and - R2 represents a methyl group, a difluoromethyl group or a trifluoromethyl group are known as active compounds with fungicidal action (see WO 1986/02641 A, WO 1992/12970 A , JP 201083869 and WO 20111/62397 A).
[0003] Furthermore, it is known that these compounds can be mixed with active ingredients; the resulting compositions being known, for example, from WO 2011/135827 A, WO 2011/135828 A, WO 2011/135830 A, WO 2011/135831, WO 2011/135832 A, WO 2011/135833 A, WO 2011/135834 AWO 2011/135835 A, WO 2011/135836 A, WO 2011/135837 A, WO 2011/135838 A, WO 2011/135839 A and WO 2011/135840 A.
[0004] Given that the ecological and economic requirements applied to modern active ingredients, for example fungicides, are constantly increasing, for example with regard to the spectrum of activity, toxicity, selectivity, application rate, waste formation and production advantages, and there may still be problems, for example with resistance, there is a constant need to develop new fungicidal compositions that have advantages over known compositions, at least in some areas.
[0005] Surprisingly, it has now been found that mixtures that include at least one compound of the formula shown above (I) and at least one biological control agent are more effective than those mixtures known from the prior art.
[0006] The mixtures according to the present invention show a greater efficiency against pathogenic microorganism, in particular phytopathogenic fungi, compared to the known compositions of the prior art.
[0007] In particular, the mixtures according to the present invention preferably have a synergistic effect with regard to their application as a pesticide against pathogenic microorganisms, in particular fungi.
[0008] Furthermore, the mixtures according to the present invention have a superior synergistic effect in comparison with the mixtures known from the prior art against pathogenic microorganisms, in particular phytopathogenic fungi.
[0009] Mixtures according to the present invention are now described in detail:
[0010] The composition according to the present invention includes (1) at least one compound of General Formula (I) formula (i)
where - R1 represents a hydrogen atom or a methyl group and - R2 represents a methyl group, a difluoromethyl group or a trifluoromethyl group; and (2) at least two compounds (II) and (III) selected from groups A to D: from the group of carboxamides; the triazole group; the group of respiratory chain inhibitors in complex III; of the group of fungicides with different modes of action since the specified compounds (II) and (III) belong to different groups (A) and (D).
[0011] Thus, the present invention is directed to the ternary mixture of the compounds of Formula (I) and compounds (II) and (III).
[0012] The compounds of Formula (I) itself have a carboxamide fraction. However, to prevent misunderstandings, the compounds of Formula (I) do not belong to the carboxamide groups referred to above in (A) as a mixing partner for the compounds of Formula (I).
[0013] The compounds of Formula (I) are known in the prior art; the preparation of the compounds is described, for example in (see WO 1986/02641 A, WO 1992/12970 A, JP 2010-83869, WO 2011/162397 A).
[0014] In a preferred embodiment of the present invention, the compound of the General Formula (I) is represented by one of the compounds (I-1) to (I-5):

[0015] The compound selected from the group consisting of the compound of Formula (I-1), (I-2) and (I-5). More preferably, the compound of the General Formula (I) is the compound of the Formula (I-1).
[0016] The compound of Formula (I) referred to as a mandatory part of the mixture according to the present invention comprises a stereocenter, as shown in the scheme above:

Thus, two stereoisomers of the compounds of Formula (I) are known, which are all part of the present invention (WO 2011/162397 A). Thus, the compound of Formula (I) is represented by Formula (I- (R))
or Formula (I- (S))
wherein the compounds of the General Formula (I- (R)) and (I- (S)) of the specific residues have the following meaning: - R1 represents a hydrogen atom or a methyl group and - R2 represents a methyl group , a difluoromethyl group or a trifluoromethyl group.
[0018] The compound of Formulas (I) can be represented by a mixture of the compounds of General Formulas (I- (S)) and (I- (R)). However, preferably, the ratio of the R-form S enantiomer to the compound of the General Formula (I) is 80/20 or more, more preferably, the ratio of the R-form S enantiomer to the compound of the General Formula (I) is 90/100 to 10000/1, much more preferably the ratio of the R / form S enantiomer to the compound of the General Formula (I) is 95/5 to 10000/1, more preferably the ratio of the R-form enantiomer to the S form of the compound of General Formula (I) is 98/1 to 1000/1.
[0019] Taking into account the preferred definitions of the substituents R1 and R2 mentioned above, the compound of the General Formula (I) is selected from one of the following compounds


[0020] Preferably, General Formula (I) is selected from the compound ((I-1 (S)), (I-1 (R)), ((I-2 (S)), (I-2 ( R)) and ((I-5 (S)), (I-5 (R)).
[0021] More preferably, the compound of the General Formula (I) is selected from the compound ((I-1 (S)) or (I-1 (R)). Ternary fungicidal mixtures
[0022] The present invention relates to new mixtures, to a process for the preparation of these mixtures, to compositions comprising these mixtures and to their use as biologically active mixtures, in particular in the control of pathogenic microorganisms in the protection of cultures and in the protecting materials and improving plant health.
[0023] Carboxamides of the General Formula
, where - R1 represents a hydrogen atom or a methyl group and - R2 represents a methyl group, a difluoromethyl group or a trifluoromethyl group are known as active compounds with fungicidal action (see WO 1986/02641 A, WO 1992/12970 A , JP 2010-83869, WO 20111/62397 A). It is obvious that they are identical to the compounds of Formula (1) presented above.
[0024] Furthermore, it is known that these compounds can be mixed with active ingredients; the resulting compositions being known, for example, from WO 2011/135827 A, WO 2011/135828 A, WO 2011/135830 A, WO 2011/135831, WO 2011/135832 A, WO 2011/135833 A, WO 2011/135834 AWO 2011/135835 A, WO 2011/135836 A, WO 2011/135837 A, WO 2011/135838 A, WO 2011/135839 A and WO 2011/135840 A.
[0025] Given that the ecological and economic requirements applied to modern active ingredients, for example fungicides, are constantly increasing, for example with regard to the spectrum of activity, toxicity, selectivity, application rate, waste formation and production advantages, and there may still be problems, for example with resistance, there is a constant need to develop new fungicidal compositions that have advantages over known compositions, at least in some areas.
[0026] Surprisingly, it has now been found that mixtures that include at least one compound of the Formula shown above (I) and at least one biological control agent are more effective than those mixtures known from the prior art.
[0027] The mixtures according to the present invention show a greater efficiency against pathogenic microorganism, in particular phytopathogenic fungi, compared to the known compositions of the prior art.
[0028] In particular, the mixtures according to the present invention preferably have a synergistic effect with regard to their application as a pesticide against pathogenic microorganisms, in particular fungi.
[0029] Furthermore, the mixtures according to the present invention have a superior synergistic effect in comparison with the mixtures known from the prior art against pathogenic microorganisms, in particular phytopathogenic fungi.
[0030] The mixtures according to the present invention are now described in detail:
[0031] The composition according to the present invention includes at least one compound of the General Formula (I)
, where - R1 represents a hydrogen atom or a methyl group and - R2 represents a methyl group, a difluoromethyl group or a trifluoromethyl group; and (2) at least two compounds (II) and (III) selected from groups A to D: (A) from the group of carboxamides; (B) of the triazole group; (D) the group of respiratory chain inhibitors in complex III; (D) of the group of fungicides with different modes of action (E) since the specified compounds (II) and (III) belong to different groups (A) and (D).
[0032] Thus, the present invention is directed to the ternary mixture of the compounds of Formula (I) and compounds (II) and (III).
[0033] The compounds of Formula (I) themselves have a carboxamide fraction. However, to prevent misunderstandings, the compounds of Formula (I) do not belong to the carboxamide groups referred to above in (A) as a mixing partner for the compounds of Formula (I).
[0034] The compounds of Formula (I) are known in the prior art; the preparation of the compounds is described, for example in (see WO 1986/02641 A, WO 1992/12970 A, JP 2010-83869, WO 2011/162397 A). In a preferred embodiment of the present invention, the compound of the General Formula (I) is represented by one of the compounds (I-1) to (I-5):


[0035] The compound of General Formula (I) is preferably selected from the group consisting of the compound of Formula (I-1), (I-2) and (I-5). More preferably, the compound of the General Formula (I) is the compound of the Formula (I-1).
[0036] The compound of Formula (I) referred to as a mandatory part of the mixture according to the present invention comprises a stereocenter, as shown in the above scheme:

Thus, two stereoisomers of the compounds of Formula (I) are known, which are all part of the present invention (WO 2011/162397 A). Thus, the compound of Formula (I) is represented by Formula (I- (R))
or Formula (I- (S))
wherein the compounds of the General Formula (I- (R)) and (I- (S)) of the specific residues have the following meaning: - R1 represents a hydrogen atom or a methyl group and - R2 represents a methyl group , a difluoromethyl group or a trifluoromethyl group.
[0038] The compound of Formulas (I) can be represented by a mixture of the compounds of General Formulas (I- (S)) and (I- (R)). However, preferably, the ratio of the R-form S enantiomer to the compound of the General Formula (I) is 80/20 or more, more preferably, the ratio of the R-form S enantiomer to the compound of the General Formula (I) is 90/100 to 10000/1, much more preferably the ratio of the R / form S enantiomer to the compound of the General Formula (I) is 95/5 to 10000/1, more preferably the ratio of the R-form enantiomer to the S form of the compound of General Formula (I) is 98/1 to 1000/1.
[0039] Taking into account the preferred definitions of the substituents R1 and R2 mentioned above, the compound of General Formula (I) is selected from one of the following compounds


[0040] Preferably, General Formula (I) is selected from the compound ((I-1 (S)), (I-1 (R)), ((I-2 (S)), (I-2 ( R)) and ((I-5 (S)), (I-5 (R)).
[0041] More preferably, the compound of the General Formula (I) is selected from the compound ((I-1 (S)) or (I-1 (R)).
[0042] The compounds of Formula (I) are mixed with at least two other pesticides, which are selected from the following groups in the carboxamide group; the triazole group; the group of respiratory chain inhibitors in complex III; of the group of fungicides with different modes of action since the specified compounds (II) and (III) belong to different groups (A) and (D).
[0043] If the compound of group (A) is used in combination with the compound of Formula (I), the compound of the groups of the carboxamides is selected from (1.1) bixafen (581809-46-3), (1.2 ) boscalid (188425-85-6), (1.3) carboxin (5234-68-4), (1.4) diflumetorim (130339-07-0), (1.5) fenfuram (24691-80-3), (1.6) fluopy (658066-35-4), (1.7) flutolanil (66332-96-5), (1.8) fluxpyroxad (907204-31-3), (1.9) furametpir (123572-88-3), (1.10) furmeciclox (60568 -05-0), (1.11) isopirazam (mixture of syn-epimeric racemate 1RS, 4SR, 9RS and anti-epimeric racemate 1RS, 4SR, 9SR) (881685-58-1), (1.12) isopirazam (anti-epimeric racemate 1RS, 4SR, 9SR), (1.13) isopyrazam (1R, 4S, 9S anti-epimeric enantiomer) (683777-14-2), (1.14) isopirazam (1S, 4R, 9R anti-epimeric enantiomer) (1130207-91- 8), (1.15) isopirazam (syn epimeric racemate 1RS, 4SR, 9RS), (1.16) isopirazam (1R, 4S, 9R synepimeric enantiomer) (1240879-17-7), (1.17) isopirazam (1S, 4R sinepimeric enantiomer) 9S) (1130207-94-1), (1.18) mepro nil (55814-41-0), (1.19) oxycarboxin (5259-88-1), (1.20) penflufen (49479367-8), (1.21) pentiopirad (183675-82-3), (1.22) silkxane (874967- 676), (1.23) tifluzamide (130000-407), (1.24) 1-methyl-N- [2- (1,1,2,2-tetrafluoroethoxy) phenyl] -3- (trifluoromethyl) -1H-pyrazol4-carboxamide (923953-99-5), (1.25) 3- (difluoromethyl) -1-methyl-N- [2- (1,1,2,2tetrafluoroethoxy) phenyl] -1H-pyrazol-4-carboxamide (923953-98- 4), (1.26) 3 (difluoromethyl) -N- [4-fluoro-2- (1,1,2,3,3,3-hexafluoropropoxy) phenyl] -1-methyl-1Hpyrazol-4-carboxamide (1172611- 40-3), (1.27) N- [1- (2,4-dichlorophenyl) -1methoxypropan-2-yl] -3- (difluoromethyl) -1- methyl-1H-pyrazol-4-carboxamide (109240095-7) , (1.28) 5,8-difluoro-N- [2- (2-fluoro-4 - {[4- (trifluoromethyl) pyridin-2yl] oxy} phenyl) ethyl] quinazolin-4-amine (1210070-84-0 ), (1.29) benzovindiflupir (1072957-71-1), (1.30) N- [(1S, 4R) -9- (dichloromethylene) -1,2,3,4-tetrahydro-1,4-methanonaftalen-5- yl] - 3- (difluoromethyl) -1-methyl-1H-pyrazol-4-carboxamide and (1.31) N - [(1R, 4S) - 9- (dichloromethylene) -1,2,3,4-tetrahi dro-1,4-methanonaphthalen-5-yl] - 3 (difluoromethyl) -1-methyl-1H-pyrazol-4-carboxamide.
[0044] If the compound of group (B) is used in combination with the compound of Formula (I), the compound of the triazole group is selected from (2.1) bitertanol (55179-31-2), ( 2.2) bromuconazole (116255-48-2), (2.3) cyproconazole (113096-99-4), (2.4) diphenoconazole (119446-68-3), (2.5) diniconazole (83657-24-3), (2.6) diniconazole-M (83657-18-5), (2.7) epoxiconazole (106325-080), (2.8) etaconazole (60207-93-4), (2.9) fenbuconazole (114369-43-6), (2.10) fenhexamid ( 126833-17-8), (2.11) fluquinconazole (136426-54-5), (2.12) flusilazole (85509-19-9), (2.13) flutriafol (76674-21-0 (2.14) hexaconazole (79983-71- 4), (2.15) imazalil (35554-44-0), (2.16) imazalil sulfate (58594-72-2), (2.17) ipconazole (125225-28-7), (2.18) metoconazole (125116-23- 6), (2.19) miclobutanil (88671-89-0), (2.20) penconazole (66246-88-6), (2.21) prochloraz (67747-09-5), (2.22) propiconazole (60207-90-1) , (2.23) protioconazole (178928-70-6), (2.24) pyributicarb (88678-67-5), (2.25) pyrifenox (88283-41-4), (2.26) q uinconazole (103970-75-8), (2.27) simeconazole (149508-90-7), (2.28) spiroxamine (11813430-8), (2.29) tebuconazole (107534-96-3), (2.30) tetraconazole (112281- 77-3), (2.31) triadimefon (43121-43-3), (2.32) triadimenol (55219-65-3), (2.33) triflumizole (68694-11-1), (2.34) triforine (26644-462) and (2.35) triticonazole (131983-72-7).
[0045] If the compound of group (C) is used in combination with the compound of Formula (I), the compound of the group of respiratory chain inhibitors in complex III is selected from (3.1) ametoctradine (86531897-4 ), (3.2) azoxystrobin (131860-33-8), (3.3) ciazofamid (120116-88-3), (3.4) dimoxystrobin (141600-52-4), (3.5) enoxastrobin (238410-11-2), (3.6) famoxadone (131807-57-3), (3.7) phenamidone (161326-34-7), (3.8) flufenoxystrobin (918162-02-4), (3.9) fluoxastrobin (361377-29-9), (3.10 ) kresoxim-methyl (143390-89-0), (3.11) metominostrobin (133408-50-1), (3.12) orisastrobin (189892-691), (3.13) picoxistrobin (117428-22-5), (3.14) piraclostrobin (175013-180), (3.15) trifloxystrobin (141517-21-7) and (3.16) N-methylalpha-methoxyimino-2 - [(2,5-dimethylphenoxy) methyl] phenylacetamide.
[0046] If the compound of group (D) is used in combination with the compound of Formula (I), the compound of the groups of fungicides with different modes of action is selected from (4.1) captan (133-06- 2), (4.2) chlorothalonil (1897-45-6), (4.3) copper hydroxide (20427-59-2), (4.4) copper naphthenate (1338-02-9), (4.5) copper oxide ( 1317-39-1), (4.6) copper oxychloride (1332-40-7), (4.7) copper sulfate (2+) (7758-98-7), (4.8) dithianone (3347-22-6) , (4.9) dodine (2439-10-3), (4.10) dodine free base (112-65-2), (4.11) ferbam (14484-64-1), (4.12) fluorofolpet (719-96-0) , (4.13) folpet (133-07-3), (4.14) guazatin (108173-90-6), (4.15) guazatin acetate (69311-74-6), (4.16) iminoctadine (13516-27-3) , (4.17) iminoctadine albesylate (16920206-6), (4.18) iminoctadine triacetate (57520-17-9), (4.19) mancobre (53988-93-5), (4.20) mancozeb (8018-01-7) , (4.21) maneb (12427-382), (4.22) meth (900642-2), (4.23) meth zinc (9006-42-2), (4.24) oxin-copper (10380-28-6), (4 .25) propamidine (104-32-5), (4.26) propineb (12071-83-9), (4.27) draw (137-26-8), (4.28) zineb (12122-67-7), (4.29 ) ziram (137-30-4), (4.30) anilazine (101-05-3), (4.31) 2,6-dimethyl-1H, 5H-dithino [2,3-c: 5,6-c '] dipyrrol-1,3,5,7 (2H, 6H) - tetrone (16114-35-5), (4.32) metalaxyl (57837-19-1), (4.33) metalaxyl-M (mefenoxam) (70630-17- 0), (4.34) fludioxonil (131341-86-1).
[0047] The compounds of Formula (I) and compounds (II) and (III) of the mixture or compositions according to the present invention can be combined with any specific proportion between these three mandatory components. In the mixtures or compositions according to the invention, the compounds of the General Formula (I) and the compounds (II) are present in a synergistically efficient weight ratio of (I): (II) In an order of 1000: 1 to 1: 1000, preferably in a weight ratio of 500: 1 to 1: 500, more preferably in a weight ratio of 100: 1 to 1: 100. Other proportions of (I): II) that can be used in accordance with the present invention with ever greater preferences in the order are: 800: 1 to 1: 800, 700: 1 to 1: 700, 750: 1 to 1: 750, 600: 1 to 1: 600, 400: 1 to 1: 400, 300: 1 to 1: 300, 250: 1 to 1: 250, 200: 1 to 1: 200, 95: 1 to 1:95, 90: 1 to 1:90, 85: 1 to 1:85, 80: 1 to 1:80, 75: 1 to 1:75, 70: 1 to 1:70, 65: 1 to 1:65, 60: 1 to 1:60, 55: 1 to 1:55, 45: 1 to 1:45, 40: 1 to 1:40, 35: 1 to 1:35, 30: 1 to 1:30, 25: 1 to 1:25, 20: 1 to 1:20, 15: 1 to 1:15, 10: 1 to 1:10, 5: 1 to 1: 5, 4: 1 to 1: 4, 3: 1 to 1: 3, 2: 1 to 1: 2.
[0048] In the mixtures or compositions according to the invention, the compounds of the General Formula (I) and the compounds (III) are present In a synergistic efficient weight ratio of (I): (III) between 1000: 1 and 1: 1000, preferably in a weight ratio of 500: 1 and 1: 500, preferably in a weight ratio of 100: 1 and 1: 100. Other propositions of (I) :( III), which can be used according to the present invention in ascending order of preference are: 800: 1 to 1: 800, 700: 1 to 1: 700, 750: 1 to 1: 750, 600: 1 to 1: 600, 400: 1 to 1: 400, 300: 1 to 1: 300, 250: 1 to 1: 250, 200: 1 to 1: 200, 95: 1 to 1:95, 90: 1 to 1:90, 85: 1 to 1:85, 80: 1 to 1:80, 75: 1 to 1:75, 70: 1 to 1:70, 65: 1 to 1:65, 60: 1 to 1:60, 55: 1 to 1:55, 45: 1 to 1:45, 40: 1 to 1:40, 35: 1 to 1:35, 30: 1 to 1:30, 25: 1 to 1:25, 20: 1 to 1:20, 15: 1 to 1:15, 10: 1 to 1:10, 5: 1 to 1: 5, 4: 1 to 1: 4, 3: 1 to 1: 3, 2: 1 to 1: 2.
[0049] In mixtures or compositions according to the invention, compounds (II) and compounds (III) are present In a synergistically efficient weight ratio of (II): (III) between 1000: 1 and 1: 1000, preferably In a weight ratio of 500: 1 and 1: 500, preferably In a weight ratio of 100: 1 and 1: 100- Other ratios of (II): (III) that can be used accordingly with the present invention in ascending order of preference are: 800: 1 to 1: 800, 700: 1 to 1: 700, 750: 1 to 1: 750, 600: 1 to 1: 600, 400: 1 to 1: 400 , 300: 1 to 1: 300, 250: 1 to 1: 250, 200: 1 to 1: 200, 95: 1 to 1:95, 90: 1 to 1:90, 85: 1 to 1:85, 80 : 1 to 1:80, 75: 1 to 1:75, 70: 1 to 1:70, 65: 1 to 1:65, 60: 1 to 1:60, 55: 1 to 1:55, 45: 1 to 1:45, 40: 1 to 1:40, 35: 1 to 1:35, 30: 1 to 1:30, 25: 1 to 1:25, 20: 1 to 1:20, 15: 1 to 1 : 15, 10: 1 to 1:10, 5: 1 to 1: 5, 4: 1 to 1: 4, 3: 1 to 1: 3, 2: 1 to 1: 2.
[0050] In general, between 0.01 and 100 parts by weight, preferably between 0.05 and 20 parts by weight, with particular preference between 0.1 and 10 parts by weight of the active compound of group (II) and between 0.01 and 100 parts by weight, preferably between 0.05 and 20 parts by weight, with particular preference between 0.1 and 10 parts by weight of active compound in group (III) are present per part by weight of the active compound according to Formula (I). The mixing ratio should preferably be selected in order to obtain a synergistic mixture.
[0051] The weight ratio (I), (II) and (III) is selected in order to obtain the desired action, for example synergistic action. In general, the weight ratio varies depending on the specific active compound. In general, the weight ratio between any of (I), (II) and (III), independently of each other, varies between 500,000: 1 and 1: 500,000, preferably 200,000: 1 and 1: 200,000 more preferably 100,000: 1 and 1: 100,000, and most preferred 50,000: 1 and 1:50,000.
[0052] Other proportions by weight between any of (I), (II) and (III), independently of each other, which can be employed according to the present invention in ascending order of preference are: 1 and 1:75 000, 25 000: 1 and 1:25 000. 20 000: 1 and 1:20 000, 10 000: 1 and 1:10 000, 5000: 1 and 1: 5000, 2500: 1 and 1: 2500, 2000: 1 and 1: 2000, 1000: 1 and 1: 1000, 750: 1 and 1: 750, 500: 1 and 1: 500, 250: 1 and 1: 250, 200: 1 and 1: 200, 100: 1 and 1: 100, 95: 1 to 1:95, 90: 1 to 1:90, 85: 1 to 1:85, 80: 1 to 1:80, 75: 1 to 1:75, 70: 1 to 1: 70, 65: 1 to 1:65, 60: 1 to 1:60, 55: 1 to 1:55, 45: 1 to 1:45, 40: 1 to 1:40, 35: 1 to 1:35, 30: 1 to 1:30, 25: 1 to 1:25, 15: 1 to 1:15, 10: 1 to 1:10, 5: 1 to 1: 5, 4: 1 to 1: 4, 3: 1 to 1: 3, 2: 1 to 1: 2.
[0053] Other proportions by weight between any of (I), (II) and (III), are 1: 200 000: 20 000, 1: 200 000: 10 000.
[0054] The preferred combinations of the compounds of the General Formula (I) with specific representatives of the class of compounds (A) to (D) are described below.
[0055] In a first preferred embodiment of the present invention, the compound of General Formula (I) is combined with at least one member of (A), the group of carboxamides, and at least one member of (B), the group of triazoles. In a preferred embodiment of the present invention, the triazole group compound (A) is protioconazole. In a preferred embodiment of the present invention, the triazole group compound (A) is epoxiconazole. In a preferred embodiment of the present invention, the compound of the triazole group (A) is cyproconazole. In a preferred embodiment of the present invention, the triazole group compound (A) is metoconazole.
[0056] In a second preferred embodiment of the present invention, the compound of General Formula (I) is combined with at least one member of the group (A), of the carboxamides, and at least one member of (C), of the group of inhibitors of the respiratory chain in complex III (C). In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is azoxystrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is pyraclostrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is picostrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is trifloxystrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is fluoxastrobin.
[0057] In a third preferred embodiment of the present invention, the compound of the General Formula (I) is combined with at least one member of the group (C), the group of respiratory chain inhibitors in complex III and at least one member of ( B), the triazole group. In a preferred embodiment of the present invention, the triazole group compound (A) is protioconazole. In a preferred embodiment of the present invention, the triazole group compound (A) is epoxiconazole. In a preferred embodiment of the present invention, the compound of the triazole group (A) is cyproconazole. In a preferred embodiment of the present invention, the triazole group compound (A) is metoconazole.
[0058] In a fourth preferred embodiment of the present invention, the compound of General Formula (I) is combined with at least one member of (D), the group of fungicides with different modes of action, and at least one member of (B ), the triazole group. In a preferred embodiment of the present invention, the triazole group compound (A) is protioconazole. In a preferred embodiment of the present invention, the triazole group compound (A) is epoxiconazole. In a preferred embodiment of the present invention, the compound of the triazole group (A) is cyproconazole. In a preferred embodiment of the present invention, the triazole group compound (A) is metoconazole.
[0059] In a fifth preferred embodiment of the present invention, the compound of General Formula (I) is combined with at least one member of the group (A), of the carboxamides, and at least one member of (D), the group of the fungicides with different modes of action and at least one member (C), of the group of respiratory chain inhibitors in complex III (C). In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is azoxystrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is pyraclostrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is picostrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is trifloxystrobin. In a preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is fluoxastrobin.
[0060] Specific examples of mixtures of this first preferred embodiment are mixtures of compounds of Formula (I) with bixafen as the compound of the carboxamide group (A) and protioconazole as the compound of the triazole group (B) or bixafen as the compound of the carboxamide group (A) and trifloxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C) or benzovindiflupir as the compound of the carboxamide group (A) and protioconazole as the compound of the triazole group (B) or fluxpyroxad as the carboxamide group compound (A) and protioconazole as the triazole group compound (B).
[0061] protioconazole as the compound of the triazole group (B) and azoxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0062] protioconazole as the compound of the triazole group (B) and pyraclostrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0063] protioconazole as the compound of the triazole group (B) and picostrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0064] protioconazole as the compound of the triazole group (B) and trifloxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0065] protioconazole as the compound of the triazole group (B) and fluoxastrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0066] epoxiconazole as the compound of the triazole group (B) and azoxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0067] epoxiconazole as the compound of the triazole group (B) and pyraclostrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0068] epoxiconazole as the compound of the triazole group (B) and picoxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0069] epoxiconazole as the compound of the triazole group (B) and trifloxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0070] epoxiconazole as the compound of the triazole group (B) and fluoxastrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0071] cyproconazole as the compound of the triazole group (B) and azoxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0072] cyproconazole as the compound of the triazole group (B) and pyraclostrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0073] cyproconazole as the compound of the triazole group (B) and picoxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0074] cyproconazole as the compound of the triazole group (B) and trifloxystrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0075] cyproconazole as the compound of the triazole group (B) and fluoxastrobin as the compound of the group of respiratory chain inhibitors in complex III (C);
[0076] protioconazole as the compound in the triazole group (B) and metalaxyl as the compound in the multi-site fungicide group (D);
[0077] protioconazole as the triazole group compound (B) and metalaxyl-M as the multi-site fungicide group compound (D);
[0078] protioconazole as the compound of the triazole group (B) and fludioxonil as the compound of the multi-site fungicide group (D);
[0079] metoconazole as the compound of the triazole group (B) and metalaxyl as the compound of the multi-site fungicide group (D);
[0080] metoconazole as the triazole group compound (B) and metalaxyl-M as the multi-site fungicide group compound (D);
[0081] metoconazole as the compound of the triazole group (B) and fludioxonil as the compound of the multi-site fungicide group (D);
[0082] pyraclostrobin as the compound in the group of respiratory chain inhibitors in complex III (C) and metalaxyl as the compound in the group of multi-site fungicides (D);
[0083] pyraclostrobin as the compound in the group of respiratory chain inhibitors in complex III (C) and metalaxyl-M as the compound in the group of multi-site fungicides (D);
[0084] pyraclostrobin as the compound in the group of respiratory chain inhibitors in complex III (C) and fludioxonil as the compound in the group of multi-site fungicides (D);
[0085] In a second preferred embodiment of the present invention, the compound of General Formula (I) is combined with at least one member of the group of carboxamides (A) and at least one member of (C), of the group of chain inhibitors complex III (C). In this second preferred embodiment of the present invention, the compound of the group of respiratory chain inhibitors in complex III (C) is trifloxystrobin.
[0086] The following combinations exemplify specific embodiments of the mixture according to the present invention:

































































[0087] Although the mixture according to the present invention may itself be a composition, the final composition used is normally prepared by mixing the compounds of Formula (I) and compounds (II) and (III) and an inert vehicle and, if necessary, adding a surfactant and / or other formulation aid, such as a diluent and formulating the mixture In an oil formulation, emulsifiable concentrate, fluid formulation, wettable powder, hydro-dispersible granules, powder, granules or the like. The formulation that is used alone or adding another inert component, can be used as a pesticide.
[0088] Other specific components of this final composition are described later.
[0089] The "composition" can be prepared by formulating the compounds of Formula (I) and compounds (II) and (III) as described above and then producing the formulations or their diluents.
[0090] For the sake of clarity, a mixture means a physical combination of the compounds of Formula (I) and compounds (II) and (III), while a composition means a combination of the mixture together with other additives, such as surfactants, solvents, vehicles, pigments, defoamers, thickeners and thinners, in a form suitable for agrochemical application.
[0091] The present invention also relates to a method for controlling harmful microorganisms, comprising contact with said harmful microorganisms or their habitat with the composition described above. The present invention also relates to a method for treating seeds, including contacting the seeds referred to with the composition described above.
[0092] Finally, the present invention also relates to seeds treated with the composition described above.
[0093] Thus, the present invention also relates to compositions to control harmful microorganisms, mainly harmful fungi and bacteria, including an effective and non-phytotoxic amount of the active ingredients of the invention. These are preferably fungicidal compositions, which include agriculturally suitable auxiliaries, solvents, vehicles, surfactants or diluents.
[0094] In the context of the present invention, "control of harmful microorganisms" means a reduction in infestation by harmful microorganisms compared to untreated plants and assessed as fungicidal efficacy, preferably a 25-50% reduction compared to untreated plants ( 100%), more preferably a reduction of 40-79% compared to the untreated plant (100%) and even more preferably, the infection by microorganism is completely suppressed (in 70-100%). The control can be curative, that is, to treat already infected plants or protective to protect plants which have not yet been infected.
[0095] An "effective but non-phytotoxic amount" means an amount of the composition of the invention, which is sufficient to control plant fungus disease In a satisfactory manner or to eradicate fungus disease completely and which, at the same time time, does not cause any significant symptoms of phytotoxicity. In general, this application rate can vary over a relatively wide range. This depends on several factors, for example, the fungi to be controlled, the plant, the climatic conditions and the ingredients of the compositions of the invention.
[0096] Suitable organic solvents include polar and non-polar organic solvents normally employed for formulation purposes. Preferably, the solvents are selected from ketones, e.g. methylisobutyl ketone and cyclohexanone, starches, e.g. dimethyl formamide and alkanecarboxylic acid amides, e.g. N, N-dimethyl decanoamide and N, N-dimethyl octanamide, even more cyclic solvents, e.g. N-methyl-pyrrolidone, N-octylpyrrolidone, N-dodecyl-pyrrolidone, N-octyl-caprolactam, N-dodecyl-caprolactam and butyrolactone, more so strong polar solvents, e.g. dimethyl sulfoxide and aromatic hydrocarbons, e.g. xilal, Solvesso ™, mineral oils, e.g. white spirit, petroleum, alkyl benzene and oil, also esters, eg. propylene glycol monomethyl acetate, adipic acid dibutylester, acetic acid hexylester, acetic acid heptyester, citric acid tri-n-butylester and phthalic acid di-butylester and also alcohols, e.g. benzyl alcohol and 1-methoxy2-propanol.
[0097] According to the invention, a vehicle is an organic or inorganic, natural or synthetic substance with which the active ingredients are mixed or combined for better applicability, in particular for application to plants or parts of plants or seeds. The vehicle, which can be solid or liquid, is normally inert and should be suitable for use in agriculture.
[0098] Useful solid or liquid vehicles include: for example, ammonium salts and natural rock powders, such as kaolin, clays, talc, chalk, quartz, atapulgite, montmorillonite or diatomaceous earth and synthetic rock powders, such as , finely divided silica, aluminum and natural or synthetic silicates, resins, waxes, solid fertilizers, water, alcohols, mainly butanol, organic solvents, vegetable and mineral oils and derivatives thereof.
[0099] Mixtures of these vehicles can also be used.
[00100] Solid fillers and suitable vehicles include inorganic particles, e.g. carbonates, silicates, sulphates and oxides with an average particle size of between 0.005 and 20 μm, preferably between 0.02 to 10 μm, for example ammonium sulphate, ammonium phosphate, urea, calcium carbonate, calcium sulphate , magnesium sulfate, magnesium oxide, aluminum oxide, silicon dioxide, called fine particle silica, silica gels, natural or synthetic silicates and aluminosilicates and plant products such as cereal flour and wood / sawdust powder and cellulose.
[00101] Solid vehicles useful for granules include: for example, crushed and fractionated natural rocks, such as calcite, marble, pumice, sepiolite, dolomite and synthetic granules of inorganic and organic foods and granules of organic materials, such as sawdust, paper, coconut shell, corncobs and tobacco stalks.
[00102] Liquefied gaseous diluents or vehicles are those liquids that are gaseous at room temperature and under atmospheric pressure, for example, aerosol propellants, such as halohydrocarbons and also butane, propane, nitrogen and carbon dioxide.
[00103] In formulations, adhesives, such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latexes, such as arabic gum, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids, such as cephalins and synthetic lecithins and phospholipids. Other additives can be minerals and vegetable oils. If the diluent used is water, it is also possible to use, for example, organic solvents as auxiliary solvents. Useful liquid solvents are essentially: aromatic compounds, such as xylene, toluene or alkylnaphthalenes, chlorinated aromatic compounds and chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or dichloromethane, aliphatic hydrocarbons such as cyclohexane or paraffins, for example mineral oil fractions mineral and vegetable oils, alcohols, such as butanol or glycol, as well as the respective ethers and esters, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents, such as dimethylformamide and dimethyl sulfoxide and also water. Compositions of the invention may additionally include other components, for example, surfactants. Useful surfactants are emulsifiers and / or foaming agents, dispersants or wetting agents with ionic or non-ionic properties, or mixtures of these surfactants. Examples of these are salts of polyacrylic acid, salts of lignosulfonic acid, salts of phenolsulfonic or naphthalenesulfonic acid, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (preferably alkylphenols or arylphenols), ester salts sulfosuccinic acid, derivatives of taurine (in particular alkyl taurates), phosphoric esters of alcohols or polyoxyethylated phenols, fatty esters of polyols and derivatives of compounds containing sulphates, sulphonates and phosphates, for example alkylaryl polyglycolic ethers, alkylsulphonates, alkylsulphates, arylsulphates, protein hydrolysates, lignosulfite and methylcellulose residual liquors. The presence of a surfactant is necessary if one of the active ingredients and / or one of the inert vehicles is insoluble in water and when the application is carried out in water. The proportion of surfactants is between 5 and 40 weight percent of the composition of the invention.
[00104] Suitable surfactants (adjuvants, emulsifiers, dispersants, protective colloids, wetting agent and adhesives) include all ionic and nonionic substances, for example, ethoxylated nonylphenols, linear or branched polyalkylene glycol ether, alkylphenol reaction products with ethylene oxide and / or propylene oxide, fatty acid reaction products with ethylene oxide and / or propylene oxide, plus fatty acid esters, alkyl sulfates, alkyl ether phosphates, aryl sulfate, ethoxylated arylalkylphenols, for example. tristyryl-phenol-ethoxylates, still arylalkylphenols ethoxylated and propoxylated as sulfated or phosphated arylalkylphenol-ethoxylates and -ethoxy and -propoxylated. Other examples are natural and synthetic water-soluble polymers, e.g. flax sulphonates, gelatin, gum arabic, phospholipids, starch, modified hydrophobic starch and cellulose derivatives, in particular, cellulose ester and cellulose ether, still polyvinyl alcohol, polyvinyl acetate, polyvinylpyrrolidone, polyacrylic acid, poly-polyacrylic acid and co-polymerised (meth) acrylic acid and (meth) acrylic acid esters and also co-polymerized methacrylic acid and methacrylic acid esters, which are neutralized with alkali metal hydroxide and optionally condensation products of naphthalene sulfonic acid salts replaced with formaldehyde.
[00105] It is possible to use dyes, such as inorganic pigments, for example iron oxide, titanium oxide and Prussian blue and organic dyes, such as alizarin, azo dyes and metallic phthalocyanine dyes and trace nutrients, such as iron salts , manganese, boron, copper, cobalt, molybdenum and zinc.
[00106] Defoamers that may be present in the formulations include, for example, silicone emulsions, long-chain alcohols, fatty acids and their salts as well as fluoro-organic substances and mixtures thereof. Examples of thickeners are polysaccharides, eg, xanthan gum or veegum, silicates, eg. atapulgite, bentonite as well as fine particle silica.
[00107] If appropriate, it is also possible to keep in mind other additional components, for example, protective colloids, binders, adhesives, thickeners, thixotropic substances, penetrants, stabilizers, sequestrants, complexing agents. In general, the active ingredients can be combined with any solid or liquid additive, commonly used for formulation purposes.
[00108] The mixtures or compositions of the invention can be used as such or, depending on their particular physical and / or chemical properties, in the form of their formulations or in the forms of use prepared from them, such as aerosols, suspension of capsules , cold fogging concentrates, hot fogging concentrate, encapsulated granules, fine granules, fluid concentrates for seed treatment, ready-to-use solutions, powder for spreading, emulsifiable concentrates, oil-in-water emulsions, water-in-oil emulsions, macrogranules , microgranules, oil-dispersible powders, oil-miscible fluidizable concentrates, oil-miscible liquids, gas (under pressure), gas-generating product, foams, pastes, pesticide-coated seeds, suspension concentrates, suspoemulsion concentrates, soluble concentrates, suspensions, wettable powders, soluble powders, powders and granules, water-soluble or dispersible granules or tablets and m water, water-soluble and water-dispersible powders for seed treatment, wettable powders, natural products and synthetic substances impregnated with active ingredient and also micro-encapsulations in polymeric substances and in seed coating materials and also cold and UV ULV mist formulations hot.
[00109] The compositions of the invention include not only formulations, which are ready for use and which can be applied with a suitable apparatus on the plant or seed, but also commercial concentrates which can be diluted with water before use. Common applications are for example dilution in water and subsequent spraying of the resulting spray liquor, application after dilution in oil, direct application without dilution, seed treatment or application of granules in the soil.
[00110] The mixtures of the invention, compositions and formulations normally contain between 0.05 and 99% by weight, 0.01 and 98% by weight, preferably between 0.1 and 95% by weight, more preferably between 0.5 and 90% active ingredient, more preferably between 10 and 70% by weight. For special applications, for example, for protecting wood and wood-based products, mixtures of the invention, compositions and formulations normally contain between 0.0001 and 95% by weight, preferably 0.001 to 60% by weight of the active ingredient.
[00111] The content of the active ingredient in the application forms prepared from the formulations can vary widely. The concentration of active ingredients in the application forms is normally between 0.000001 to 95% by weight, preferably between 0.0001 and 2% by weight.
[00112] The mentioned formulations can be prepared in a manner known per se, for example, by mixing the active ingredients with at least one diluent, solvent, adjuvant, emulsifier, usual dispersant and / or binder or fixative, wetting agent, repellent of water, if appropriate desiccants and UV stabilizers and, if appropriate, dyes and pigments, defoamers, preservatives, organic and inorganic thickeners, adhesives, gibberellins and also other processing aids and also water. Depending on the type of formulation to be prepared, further processing steps are required, eg wet grinding, dry grinding and granulation. The mixtures and compositions of the invention can be present as such or in their (commercial) formulations and in the forms of use prepared from these formulations as a mixture with other (known) active ingredients, such as insecticides, baits, sterilizing agents, bactericides, acaricides, nematicides, fungicides, growth regulating substances, herbicides, fertilizers, protectors and / or semi-chemicals.
[00113] The treatment of the invention of plants and plant parts with mixtures or compositions is carried out directly or by action in the surrounding areas, habitat or storage space by the usual treatment methods, for example, by immersion, spraying, atomization, irrigation, evaporation, powders, fogging, foams, paints, spreading, irrigation (impregnation), drip irrigation and, in the case of propagating material, mainly in the case of seeds, also by dry treatment of the seeds, wet treatment of the seeds , sludge treatment, encrustation, coating with one or more layers, etc. It is also possible to apply mixtures or compositions by the ultra-low volume method to inject the preparation of mixtures or compositions or the active ingredient itself into the soil. Plant / Crop Protection
[00114] Mixtures or compositions have a potent microbicidal activity and can be used to control harmful microorganisms, such as fungi and bacteria, in crop protection and material protection. The invention also relates to a method for controlling harmful microorganisms, characterized in that the mixtures or compositions of the invention are applied to phytopathogenic fungi, phytopathogenic bacteria and / or their habitats.
[00115] Fungicides can be used in crop protection to control phytopathogenic fungi. These are characterized by excellent efficacy against a broad spectrum of phytopathogenic fungi, including soil pathogens, which are in particular members of the Plasmodioforomycetes classes,
[00116] Peronosporomycetes (Syn. Oomycetes), Citridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (Syn. Fungi imperfecti). Some fungicides are systematically active and can be used to protect the plant as a foliar application, seed coating or soil fungicide. Furthermore, they are suitable for combating fungi, which inter alia infest wood or plant roots.
[00117] Bactericides can be used in protection to control Pseudomonadaceae, Rizobiaceae, Enterobacteriaceae, Corinebacteriaceae and Streptomicetaceae.
[00118] Non-limiting examples of pathogens or fungal diseases that can be treated according to the invention include:
[00119] diseases caused by pathogens of powdery mildew, for example, species of Blumeria, for example Blumeria graminis; Podosphaera species, for example Podosphaera leucotricha; Sphaerotheca species, for example Sphaerotheca fuliginea; species of Uncinula, for example Uncinula necator; diseases caused by rust pathogens, for example, Gymnosporangium species, for example, Gymnosporangium sabinae; Hemileia species, for example, Hemileia vastatrix; Phakopsora species, for example, Phakopsora pachyrhizi and Phakopsora meibomiae; Puccinia species, for example, Puccinia recondite, P. triticina, P. graminis or P. striiformis; Uromyces species, for example, Uromyces appendiculatus;
[00120] diseases caused by pathogenic agents of the Oomycetes group, for example Albugo species, for example Algubo candida; Bremia species, for example Bremia lactucae; Peronospora species, for example Peronospora pisi or P. brassicae; Phytophthora species, for example Phytophthora infestans; Plasmopara species, for example Plasmopara viticola; species of Pseudoperonospora, for example Pseudoperonospora humuli or Pseudoperonospora cubensis; Pythium species, for example Pythium ultimum;
[00121] leaf spot diseases and tracheomycosis caused, for example, by Alternaria species, for example Alternaria solani; species of Cercospora, for example Cercospora beticola; Cladiosporium species, for example Cladiosporium cucumerinum; species of Cochliobolus, for example Cochliobolus sativus (form of conidia: Drechslera, Syn: Helminthosporium), Cochliobolus miyabeanus; Colletotrichum species, for example, Colletotrichum lindemuthanium; Cycloconium species, for example, Cycloconium oleaginum; Diaporthe species, for example, Diaporthe citri; Elsinoe species, for example, Elsinoe fawcettii; Gloeosporium species, for example, Gloeosporium laeticolor; Glomerella species, for example, Glomerella cingulata; Guignardia species, for example, Guignardia bidwelli; Leptosphaeria species, for example, Leptosphaeria maculans, Leptosphaeria nodorum; Magnaporthe species, for example, Magnaporthe grisea; Microdochium species, for example, Microdochium nivale; Mycosphaerella species, for example, Mycosphaerella graminicola, M. arachidicola and M. fijiensis; species of Phaeosphaeria, for example, Phaeosphaeria nodorum; Pyrenophora species, for example, Pyrenophora teres, Pyrenophora tritici repentis; Ramularia species, for example, Ramularia collo-cygni, Ramularia areola; Rhynchosporium species, for example, Rhynchosporium secalis; Septoria species, for example, Septoria apii, Septoria lycopersii; Typhula species, for example, Typhula incarnata; Venturia species, for example, Venturia inaequalis;
[00122] diseases of the root and stem caused, for example by species of Corticium, for example Corticium graminearum; Fusarium species, for example Fusarium oxysporum; Gaeumannomyces species, for example Gaeumannomyces graminis; Rhizoctonia species, such as for example Rhizoctonia solani; Sarocladium diseases caused, for example, by Sarocladium oryzae; Sclerotium diseases caused, for example, by Sclerotium oryzae; Tapesia species, for example Tapesia acuformis; Thielaviopsis species, for exampleThielaviopsis basicola;
[00123] diseases of the ear and panicle (including ears of corn) caused, for example, by species of Alternaria, for example Alternaria spp .; Aspergillus species, for example Aspergillus flavus; Cladosporium species, for example Cladosporium cladosporioides; species of Claviceps, for example Claviceps purpurea; Fusarium species, for example Fusarium culmorum; Gibberella species, for example Gibberella zeae; Monographella species, for example Monographella nivalis; Septoria species, for example Septoria nodorum;
[00124] diseases caused by saddle bags, for example Sphacelotheca species, for example Sphacelotheca reiliana; Tilletia species, for example Tilletia caries, T. controversa; Urocystis species, for example Urocystis occulta; Ustilago species, for example Ustilago nuda, U. nuda tritici;
[00125] fruit rot, for example, by Aspergillus species, for example Aspergillus flavus; Botrytis species, for example Botrytis cinerea; Penicillium species, for example Penicillium expansum and P. purpurogenum; Sclerotinia species, for example Sclerotinia sclerotiorum; Verticilium species, for example Verticilium alboatrum;
[00126] deterioration of the seed and soil, diseases caused by mold, weakening and rotting, for example, by species of Alternaria, caused for example by Alternaria brassicicola; Aphanomyces species, caused for example by Aphanomyces euteiches; Ascochyta species, caused for example by Ascochyta lentis; Aspergillus species, caused for example by Aspergillus flavus; species of Cladosporium, caused for example by Cladosporium herbarum; species of Cochliobolus, caused for example by Cochliobolus sativus; (forms of conidia: Drechslera, Bipolaris Syn: Helminthosporium); Colletotrichum species, caused for example by Colletotrichum coccodes; Fusarium species, caused for example by Fusarium culmorum; Gibberella species, caused for example by Gibberella zeae; Macrophomina species, caused for example by Macrophomina phaseolina; Monographella species, caused for example by Monographella nivalis; Penicillium species, caused for example by Penicillium expansum; Phoma species, caused for example by Phoma lingam; Phomopsis species, caused for example by Phomopsis soybean; Phytophthora species, caused for example by Phytophthora cactorum; Pyrenophora species, caused for example by Pyrenophora graminea; Pyricularia species, caused for example by Pyricularia oryzae; Pythium species, caused for example by Pythium ultimum; Rhizoctonia species, caused for example by Rhizoctonia solani; Rhizopus species, caused for example by Rhizopus oryzae; species of Sclerotium, caused for example by Sclerotium rolfsii; Septoria species, caused for example by Septoria nodorum; Typhula species, caused for example by Typhula incarnata; Verticillium species, caused for example by Verticillium dahliae;
[00127] cancers, galls, witches' broom disease, for example, Nectria species, for example, Nectria galligena;
[00128] tracheomycosis caused, for example, by species of Monilinia for example Monilinia laxa;
[00129] leaf roughness and flaking disease, caused, for example, by Exobasidium species, for example Exobasidium vexans; Taphrina species, such as, for example Taphrina deformans; diseases caused by the decline of wood plants, caused, for example, by Esca diseases, caused, for example, by Phaemoniella clamydospora, Phaeoacremonium aleophilum and Fomitiporia mediterranea; caused by Eutypa for example Eutypa lata; Ganoderma diseases caused, for example, by Ganoderma boninense; Rigidoporus diseases caused, for example, Rigidoporus lignosus;
[00130] flower and seed diseases caused, for example, by Botrytis species, for example Botrytis cinerea;
[00131] tuber diseases caused for example by Rhizoctonia species, for example Rhizoctonia solani; species
[00132] Helminthosporium, for example Helminthosporium solani; claviform root disease caused, for example, by Plasmodiophora species, for example Plamodiophora brassicae;
[00133] diseases caused by bacterial pathogenic agents, for example, by Xanthomonas species, for example Xanthomonas campestris pv. oryzae; species of Pseudomonas, for example Pseudomonas syringae pv. lachrymans; species of Erwinia, for example Erwinia amylovora.
[00134] The following soybean diseases can be controlled with preference:
[00135] Fungal diseases of leaves, stems, pods and seeds caused by, for example, Alternaria leaf spot (Alternaria spec. Atrans tenuissima), Anthracnose (Colletotrichum gloeosporoides dematium var. Truncatum), brown spot (Septoria glycines), blight leaf spot and cercosporiosis (Cercospora kikuchii), Choanephora leaf blight (Choanephora infundibulifera trispora (Syn.)), dactuliofora leaf spot (Dactuliophora glycines), downy mildew (Peronospora manshurica), drechsera-rot (drechslera) (Cercospora sojina), leaf spot by leptosphaerulina (Leptosphaerulina trifolii), leaf spot by phyllostica (Phyllostictaoyaecola), pod rot and stem (Phomopsis soye), downy mildew (Microsphaera diffusa), leaf spot by pyrenochacines (Pyrenochaetes), Pyrenochacines and Pyrenochaetes aerial plants and foliage (Rhizoctonia solani), rust (Phakopsora pachyrhizi, Phakopsora meibomiae), crusts (Sphaceloma glycines), stenfiliosis (Stemphyl ium botryosum), target spot (Corynespora cassiicola);
[00136] fungal diseases in the roots and at the base of the stem caused, for example, by root rot (Calonectria crotalariae), black root rot (Macrophomina phaseolina), fusariosis, root rot and pods and colon rot (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), root rot caused by mycoleptodiscus (Mycoleptodiscus terrestris), neocosmospora (Neocosmospora vasinfecta), pod and stem rot (Diaporthe phaseolorum), stem cancer (Diaporthe phaseolorum fit) caulivora var. Phytophthora megasperma), brown stem rot (Phialophora gregata), Pythium rot (Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), root rot, stem atrophy and stunting, Rhinoplasty (Rhino) by sclerotin (Sclerotinia sclerotiorum), sclerotin rot (Sclerotinia rolfsii), root rot by thielaviopsis (Thielaviopsis basicol The).
[00137] The fungicidal mixtures or compositions of the invention can be used for curative or protective / preventive control of phytopathogenic fungi. The invention therefore also relates to curative and protective methods for controlling phytopathogenic fungi by using the active ingredients or compositions of the invention, which are applied to the seed, plant or parts of plants, fruit or soil in which the plants grow.
[00138] The fact that the active ingredients are well tolerated by plants in the concentrations required to control plant disease, allows the treatment of plant parts above ground, vegetative propagation and seeds and soil.
[00139] According to the invention all plants and parts of plants can be treated. "Plants" means all plants and plant populations, such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not covered by plant variety or plant breeder rights). Cultivars and varieties of plants can be plants obtained by conventional propagation and reproduction methods, which can be assisted or supplemented by one or more biotechnological methods, such as, by using double haploids, protoplast fusion, random and directed mutagenesis, markers molecular or genetic or by bioengineering and genetic engineering methods. Plant parts are understood to mean all parts above and below ground and plant organs, such as shoots, leaves, flowers and roots, in which, for example, leaves, needles, stems, branches, flowers, bodies of fruits, fruits and seeds as well as roots, tubers and rhizomes are indicated. The parts of the plant also include harvested material and vegetative and generative propagation material, for example, cuttings, tubers, rhizomes, seedlings and seeds.
[00140] The mixtures or compositions of the invention, when well tolerated by plants, have a favorable homeothermic toxicity and are well tolerated by the environment, are suitable for the protection of plants and plant organs, to increase the yield of crops and to improve the quality of the material collected. These can preferably be used as crop protection compositions. They are active against species with normal sensitivity and resistance and against all or some stages of development.
[00141] Plants that can be treated according to the invention include the following main crop plants: corn, soy, alfalfa, cotton, sunflower, Brassica seed oil, such as Brassica napus (eg canola, rapeseed oil ), Brassica rapa, B. juncea (eg mustard (from the field)) and Brassica carinata, Arecaceae sp. (eg palm oil, coconut), rice, wheat, sugar beet, sugar cane, oats, rye, barley, millet and sorghum, triticale, flax, nuts, grapes and vine and various fruits and vegetables of various botanical rates , for example. Rosaceae sp. (eg pomoids such as apples and pears, but also stone fruits such as apricots, cherries, almonds, plums and peaches and red fruits, such as strawberries, raspberries, red and black currants), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp. (e.g. olive), Actinidaceae sp., Lauraceae sp. (eg avocado, cinnamon, camphor), Musaceae sp. (eg banana trees and plantations), Rubiaceae sp. (eg coffee), Theaceae sp. (eg tea), Sterculiceae sp., Rutaceae sp. (eg lemons, oranges, tangerines and grapefruits); Solanaceae sp. (eg tomatoes, potatoes, peppers, capsicum, eggplants, tobacco), Liliaceae sp., Compositae sp. (eg, lettuce, artichokes and chicory - including chicory, endive or common chicory roots), Umbelliferae sp. (eg, carrot, parsley, celery and horseradish), Cucurbitaceae sp. (eg cucumbers - including butterflies, pumpkins, watermelons, gourds and melons), Alliaceae sp. (eg leeks and onions), Cruciferae sp. (eg white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak choi, radish, horseradish, watercress, Chinese cabbage), Leguminosae sp. (eg, peanuts, peas, lentils and beans - eg beans (creepers) and broad beans), Chenopodiaceae sp. (for example, chard, fodder beet, spinach, beet roots), Malvaceae sp. (eg, okra, cocoa), Papaveraceae (eg poppy), Asparagaceae (eg asparagus); useful plants and ornamental plants in the garden and woods, including grass, herbs and lawn and Stevia rebaudiana; and in each case genetically modified types of these plants. A particularly preferred plant is soy.
[00142] In particular, the mixtures and compositions according to the invention are suitable for controlling the following plant diseases:
[00143] Albugo spp. (white oxidation formation) in ornamental plants, vegetable crops (eg A. candida) and sunflowers (eg A. tragopogonis); Alternaria spp. (black leaf spot, black spot) on vegetables, rapeseed (eg A. brassicola or A. brassicae), sugar beet (eg A. tenuis), fruit, rice, soybeans and also potatoes (eg A. solani or A. alternata) and tomatoes (eg A. solani or A. alternata) and Alternaria spp. (black head) in wheat; Aphanomyces spp. in sugar beet and vegetables; Ascochyta spp. in cereals and vegetables, e.g. A. tritici (leaf pest - Ascochyta) in wheat and A. hordei in barley; Bipolaris and Drechslera spp. (teleomorphic phase: Cochliobolus spp.), e.g. leaf spot disease (D. maydis and B. zeicola) in corn, e.g. septoriosis (B. sorokiniana) in cereals and e.g. B. oryzae on rice and grass; Blumeria (old name: Erysiphe) graminis (downy mildew) on cereals (eg wheat or barley); Botryosphaeria spp. (‘Slack Dead Arm Disease’) on the vines (eg B. obtusa);
[00144] Botrytis cinerea (teleomorphic phase: Botryotinia fuckeliana: gray mold, red rot) in soft fruits and seed fruits (inter alia strawberries), vegetables (inter alia lettuce, carrots, celery and cabbages), rapeseed oil, flowers , vines, forest crops and wheat (ear mold); Bremia lactucae (peronospora) on lettuce; Ceratocystis (syn. Ophiostoma) spp. (blue-spotted fungus) in deciduous and evergreen trees, eg C. ulmi (Dutch elm disease) in elm trees; Cercospora spp. (Cereospora leaf spot) in maize (eg C. zeae-maydis), rice, sugar beet (eg C. beticola), sugar cane, vegetables, coffee, soy (eg C. sojina or C kikuchil) and rice; Cladosporium spp. in tomatoes (eg C. fulvum: tomato leaf mold) and cereals, eg. C. herbarum (ear rot) in wheat; Claviceps purpurea (praganas) in cereals; Cochliobolus (anamorphic phase: Helminthosporium or Bipolaris) spp. (leaf spot) in corn (eg C. carbonum), cereals (eg C. sativus, anamorphic phase: B. sorokiniana: septoriosis) and rice (eg C. miyabeanus, anamorphic phase: H. oryzae) ; Colletotrichum (teleomorphic phase: Glomerella) spp. (anthracnose) on cotton (eg C. gossypii), corn (eg C. graminicola: stem rot and anthracnose), soft fruits, potatoes (eg C. coccodes: trachomycosis), beans (eg C. lindemuthianum) and soy (eg C. truncatum); Corticium spp., E.g. C. sasakii (scabbard burning) in rice; Corynespora cassiicola (leaf spot) in soybeans and ornamental plants; Cycloconium spp., E.g. C. oleaginum in olives; Cylindrocarpon spp. (eg cancer of fruit trees or black vine feet, teleomorphic phase: Nectria or Neonectria spp.) in fruit trees, vines (eg C. liriodendn; teleomorphic phase: Neonectria liriodendri, black foot disease) and many ornamental trees; Dematophora (teleomorphic phase: Rosellinia) necatrix (root / stem rot) in soybean; Diaporthe spp. for example. D. phaseolorum (stem disease) in soybean; Drechslera (syn. Helminthosporium, teleomorphic phase: Pyrenophora) spp. in corn, cereals, such as barley (eg D. teres, netting) and wheat (eg D. tritici-repentis: DTR leaf spot), rice and grass; Esca disease (death of the vine, stroke) on the vines, caused by Formitiporia (syn. Phellinus) punctata, F mediterranea. Phaeomoniella chlamydospora (old name Phaeoacremonium chlamydosporum), Phaeoacremonium aleophilum and / or Botryosphaeria obtusa; Elsinoe spp. pigeons (E. pyri) and soft fruits (E. veneta: anthracnose) and also vines (E. ampelina: anthracnose); Entyloma oryzae (soot on the leaf) in Epicoccum spp. black head) in wheat; Erysiphe spp. (downy mildew) on sugar beet (E. betae), vegetables (eg E. pisi), such as cucumber species (eg E. cichoracearum) and cabbage species, such as rapeseed (eg E. cruciferarum ); Eutypa fata (Eutypa cancer or death, anamorphic phase: Cytosporina lata, syn. Libertella blepharis) in fruit trees, vines and many ornamental trees; Exserohilum (syn. Helminthosporium) spp. in maize (eg E. turcicum); Fusarium (teleomorphic phase: Gibberella) spp. (trachomycosis and root rot) in several plants, such as e.g. F. graminearum or F. culmorum (root rot and silver top) in cereals (eg wheat or barley), F. oxysporum in tomatoes, F. solani in soy and F. verticillioides in corn; Gaeumannomyces graminis (takeall - black foot) in cereals (eg wheat or barley) and corn; Gibberella spp. in cereals (eg G. zeae) and rice (eg G. fujikuroi: bakanae disease); Glomerella cingulata on vines, seed fruits and other plants and G. gossypii on cotton; grainstaining complex on rice; Guignardia bidwellii (black rot) on Gymnosporangium spp. in Rosaceae and juniper, e.g. G. sabinae (red spider / rust) on pears; Helminthosporium spp. (syn. Drechslera, teleomorphic phase: Cochliobolus) in corn, cereals and rice; Hemileia spp., E.g. H. vastatrix (coffee rust) in coffee; Isariopsis clavispora (syn. Cladosporium vitis) on the vines; Macrophomina phaseolina (syn. Phaseoli) (root / stem rot) in soybeans and cotton; Microdochium (syn. Fusarium) nivale (snow pink mold) in cereals (eg wheat or barley); Microsphaera diffusa (downy mildew) in soybean; Monilinia spp., E.g. M. laxa. M. fructicola and M. fructigena (branch and flower pest) in stone fruit and other Rosaceae; Mycosphaerella spp. in cereals, bananas, soft fruits and peanuts, such as, for example, M. graminicola (anamorphic phase: Septoria tritici, Septoria leaf spot) in wheat or M. fijiensis (Sigatoka disease) in bananas; Peronospora spp. (peronospora) on cabbage (eg P. brassicae), rapeseed (eg P. parasitica), bulb plants (eg P. destructor), tobacco (P. tabacina) and soy (eg P. manshurica) ; Phakopsora pachyrhizi and P. meibomiae (soybean rust) in soybean; Phialophora spp. for example. on vines (eg P. tracheiphila and P. tetraspora) and soy (eg P. gregata: stem disease); Phoma lingam (root and stem rot) in soybeans and cabbage and P. betae (leaf spot) in sugar beet; Phomopsis spp. in sunflowers, vines (eg P. viticola: dead arm disease) and soybeans (eg stem gangrene / stem rot: P. phaseoli, teleomorphic phase: Diaporthe phaseolorum); Physoderma maydis (brown spot) in corn; Phytophthora spp. (trachomycosis, root, leaf and fruit rot) in various plants, such as in pepper and cucumber species (eg P. capsici), soy (eg P. megasperma, syn. P. soye), potatoes and tomatoes (eg P. infestans. late rust and brown rot) on deciduous trees (eg P. ramorum sudden death of the oak); Plasmodiophora brassicae (claviform root) in cabbages, rapeseed, radish and other plants; Plasmopara spp., E.g. P. viticola (peronospora on vines, downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (downy mildew) on Rosaceae, hops, seed fruits and berries, eg. P. leucotricha in the apple; Polymyxa spp., E.g. in cereals, such as barley and wheat (P. graminis) and sugar beet (P. betae) and the viral diseases transmitted by them;
[00145] Pseudocercosporella herpotrichoides (eye spot / stem break, teleomorphic phase: Tapesia yallundae) in cereals, eg. wheat or barley; Pseudoperonospora (peronospora) in various plants, e.g. P. cubensis in cucumber species or P. humili on hops; Pseudopezicula tracheiphila (angular leaf burn, Phialophora anamorphic) on vines; Puccinia spp. (rust disease) in various plants, e.g. P. triticina (brown rust of wheat), P. striiformis (yellow rust). P. hordei (dwarf leaf rust), P. graminis (black rust) or P. recondita (brown rye rust) in cereals, such as, for example, barley or rye. P. kuehnii in sugar cane and, for example, asparagus (eg P. asparagi); Pyrenophora (anamorphic phase: Drechslera) tritici-repentis (speckled leaf spot) in wheat orP. teres (netting) in barley; Pyricularia spp., E.g. P. oryzae (teleomorphic phase:
[00146] Magnaporthe grisea. pyriculariosis of rice) in rice and P. grisea in the lawn and cereals; Pythium spp. (weakening) of grass, rice, wheat, cotton, rapeseed, sunflowers, sugar beet and other plants (eg P. ultimum or P. aphanidermatum); Ramularia spp., E.g. R. collo-cygni (Ramularia leaf and grass spot // physiological leaf spot) in barley and R. beticola in sugar beet; Rhizoctonia spp. on cotton, rice, potatoes, turf, maize, rapeseed, sugar beet, vegetables and various other plants, for example, R. solani (root and stem rot) in soy, R. solani (sheath burning) in rice or R cerealis (crazy corn) in wheat or barley; Rhizopus stolonifer (soft rot) in strawberries, carrots, cabbages, vines and tomatoes; Rhynchosporium secalis (leaf spot) in barley, wheat and triticale; Sarocladium oryzae and S. attenuatum (scabbard burning) in rice; Sclerotinia spp. (callus rot or white) in vegetables and field crops, such as rapeseed, sunflowers (eg Sclerotinia sclerotiorum) esoja (eg S. rolfsii), • Septoria spp. on various plants, e.g. glycines (leaf spot) in soy, S. tritici (Septoria leaf spot) in wheat and S. (syn. Stagonospora) nodorum (leaf spot and septoriosis) in cereals;
[00147] Uncinula (syn. Erysiphe) necator (downy mildew, anamorphic phase: Oidium tuckeri) on the vines; Setospaeria spp. (leaf spot) on corn (e.g. S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (soot on the head) in corn, (e.g. S. reiliana: grain stain), downy mildew and sugar cane;
[00148] Sphaerotheca fuliginea (downy mildew) in cucumber species; Spongospora subterranea (floury skin) in potatoes and the viral diseases transmitted by them; Stagonospora spp. in cereals, e.g. S. nodorum (leaf spot and septoriosis, teleomorphic phase: Leptosphaeria [syn. Phaeosphaeria] nodorum) in wheat; Synchytrium endobioticum in potatoes (warty potato scab); Taphrina spp., E.g. T. deformans (frizzy leaf disease) in peaches and T. pruni (plum pockets) in plums; Thielaviopsis spp. (black root rot) in tobacco, pome, vegetable crops, soy and cotton, eg. T. basicola (syn. Chalara elegans); Tilletia spp. (bunt or stinking smut) in cereals, such as, for example. T. tritici (syn. T. caries, wheat caries) eT. controversial ("dwarf bunt") in wheat; Typhula incarnata (gray snow mold) in barley and wheat; Urocystis spp., E.g. U. occulta (flag smut) in rye; Uromyces spp. (rust) in plant plants, such as beans (eg U. appendiculatus, syn. U. phaseolI) and sugar beet (eg U. betae); Ustilago spp. (loose soot) in cereals (eg U. nuda and U. avaenae), corn (eg U. maydis: corn soot) and sugar cane; Venturia spp. (scab) on apples (eg V. inaequalis) and pears and Verticillium spp. (trachomycosis of leaves and shoots) in various plants, such as fruit trees and ornamental trees, vines, seed fruits, vegetables and field crops, such as, e.g. V. dahliae in strawberries, rapeseed, potatoes and tomatoes.
[00149] The mixtures and compositions according to the present inventions are, in particular, preferred to control the following plant diseases: Soy diseases: Cercospora kikuchii, Elsinoe glycines, Diaporthe phaseolorum var. oyae, Septaria glycines, Cercospora sojina, Phakopsora pachyrhizi, Phytophthoraoyae, Rhizoctonia solani, Corynespora casiicola, and Sclerotinia sclerotiorum. Plant health
[00150] The mixtures and compositions according to the present inventions are suitable to enhance the health of the plant.
[00151] Intensifying plant health means that mixtures or compositions of the invention can be used as plant growth regulators as defined below, as a reinforcement / resistance inducing compound as defined below, to affect plant physiology as defined below and to increase crop yield as defined below. Plant Growth Regulator
[00152] In some cases, mixtures or compositions of the invention may, at particular concentrations or rates of application, also be used as herbicides, protectors, growth regulators or agents to improve the properties of the plant, or as microbicides, for example, as fungicides, antimycotics, bactericides, viricides (including compositions against viroids) or as compositions against MLO (mycoplasma-like organisms) and RLO (Rickettsia-like organisms). If appropriate, they can also be used as intermediates or precursors for the synthesis of other active ingredients.
[00153] The active ingredients of the mixture or composition of the invention intervene in the metabolism of plants and can, therefore, also be used as growth regulators.
[00154] Plant growth regulators can have several effects on plants. The effect of substances depends essentially on the time of application in relation to the plant's development stage, and also on the amounts of active ingredient applied to the plants or their environment and the type of application. In each case, growth regulators should have a particular desired effect on crop plants.
[00155] The compounds to regulate the growth of plants can be used, for example, to inhibit the vegetative growth of plants. This inhibition of growth is of economic interest, for example, in the case of grass, since it is thus possible to reduce the frequency of mowing in ornamental gardens, parks and sports facilities, on the sides of roads, in airports or in the harvest of fruits . Equally significant is the inhibition of the growth of herbaceous and wood plants on the side of roads and in the vicinity of pipelines or overhead cables, or normally calm areas where vigorous plant growth is not desired. Equally important is the use of growth regulators to inhibit the longitudinal growth of the cereal. This reduces or completely eliminates the risk of housing the plants before harvest. In addition, growth regulators, in the case of cereals, can strengthen the stem, which also prevents housing. The use of growth regulators to reduce and strengthen the stems allows the implementation of higher volumes of fertilizers to increase yield, without any risk of accommodation for cereal cultivation.
[00156] In many cultivation plants, the inhibition of vegetative growth allows a more dense sowing and, thus, it is possible to achieve higher yields based on the surface of the soil. Another advantage of smaller plants obtained in this way is that the crop is easier to grow and harvest.
[00157] Inhibiting the growth of vegetative plants can also lead to increased yields since nutrients and assimilants are of greater benefit for the formation of the flower and the fruit than for the vegetative parts of the plants.
[00158] Often, growth regulators can also be used to promote vegetative growth. This is of great benefit when harvesting parts of the vegetative plant. However, promoting vegetative growth also promotes generative growth in which more assimilators are formed, resulting in a greater amount of fruit or greater fruit.
[00159] In some cases, the increase in yield can be achieved by manipulating the plant's metabolism, without any detectable changes in vegetative growth. In addition, growth regulators can be used to change the composition of plants, which, in turn, can result in an improvement in the quality of harvested products. For example, it is possible to increase the sugar content in sugar beet, sugar cane, pineapples and citrus fruits or to increase the protein content in soy or cereals. It is also possible, for example, to use growth regulators to inhibit the degradation of unwanted ingredients, for example sugar in sugar beet or sugar cane before or after harvest. It is also possible to positively influence the production or elimination of secondary ingredients from the plant. An example is the stimulation of the latex flow in the rubber tree.
[00160] Under the influence of growth regulators, parthenocarpic fruits can be formed. In addition, it is possible to influence the gender (sex) of the flowers. It is also possible to produce sterile pollen, which is of great importance in the reproduction and production of hybrid seed.
[00161] The use of growth regulators can control the branching of plants. On the one hand, by breaking the apical dominance, it is possible to promote the development of lateral shoots, which can be highly desirable particularly in the cultivation of ornamental plants, also in combination with a growth inhibitor. On the other hand, however, it is also possible to inhibit the growth of lateral shoots. This effect is of particular interest, for example, in growing tobacco or growing tomatoes. Under the influence of growth regulators, the amount of leaves on the plants can be controlled so that plant defoliation is achieved at the desired time. This defoliation plays a major role in the mechanical harvesting of cotton, but it is also of interest to facilitate the harvesting of other crops, for example, in winemaking. Defoliation of plants can also be assumed to reduce plant transpiration before transplanting.
[00162] Growth regulators can also be used to regulate the dehiscence of the fruit. On the one hand, it is also possible to prevent premature dehiscence of the fruit. On the other hand, it is also possible to promote the dehiscence of the fruit or even to abort the flower to achieve a desired mass ("reduction") in order to eliminate alternation. Alternation means the characteristic of some fruit species, for endogenous reasons, in presenting very different yields from year to year. Finally, it is possible to use growth regulators at the time of harvesting to reduce the forces required to harvest the fruit in order to allow mechanical harvesting or to facilitate manual harvesting.
[00163] Growth regulators can also be used to achieve faster or even delay the maturation of the material harvested before or after harvest. This is particularly advantageous as it allows an ideal fit to the requirements of the market. Furthermore, growth regulators can, in some cases, improve the color of the fruit. Furthermore, growth regulators can also be used to concentrate maturation within a certain period of time. This establishes the prerequisites for completing mechanical or manual harvesting in a single operation, for example, in the case of tobacco, tomatoes or coffee.
[00164] When using growth regulators, it is additionally possible to influence the rest of the seed or buds of the plants, so that the plants, such as pineapples or ornamental plants in nurseries, for example, germinate, sprout or bloom at a time when that normally is not supposed to happen. In areas where there is a risk of frost, it may be desirable to delay the sprouting or germination of seeds with the help of growth regulators in order to avoid damage resulting from late frosts.
[00165] Finally, plant regulators can induce plant resistance to frost, drought or high soil salinity. This allows for the cultivation of plants in regions that are normally unsuitable for this purpose. Resistance Induction
[00166] The active compounds according to the invention also exhibit a potent reinforcing effect on plants. Consequently, these can be used to mobilize the plant's defense system against the attack of unwanted microorganisms.
[00167] Substances (resistance inducers) that strengthen plants designate, in the present context, those substances that have the capacity to stimulate the defense system of plants so that treated plants, when subsequently inoculated with unwanted microorganisms, develop a high level resistance to these microorganisms.
[00168] The active compounds according to the invention are also suitable for increasing the yield of cultures. In addition, they have reduced toxicity and are well tolerated by plants.
[00169] Furthermore, in the context of the present invention, the effects of plant physiology include the following:
[00170] Tolerance to abiotic stress, including temperature tolerance, drought tolerance and recovery after drought stress, efficacy in water use (correlating to reduced water consumption), flood tolerance, ozone stress and UV tolerance, tolerance for chemicals such as heavy metals, salts, pesticides (protectors) etc.
[00171] Tolerance to biotic stress, including increased resistance to fungi and increased resistance against nematodes, viruses and bacteria. In the context of the present invention, tolerance to biotic stress preferably includes increased resistance to fungi and increased resistance to nematodes.
[00172] Increased plant vigor, including plant quality and seed vigor, reduced position failure, improved appearance, increased recovery, improved greening effect and improved photosynthetic efficiency.
[00173] Effects on plant hormones and / or functional enzymes.
[00174] Effects on growth regulators (promoters), including early germination, better germination, more developed root system and / or improved root growth, greater tillering capacity, more productive canes, early flowering, greater plant height and / or biomass, reduced stems, improved shoot growth, number of grains / ears, number of ears / m2, number of stolons and / or number of flowers, increased harvest rate, larger leaves, less dead basal leaves, improvement philataxia, early ripening / early ripening of the fruit, homogeneous ripening, longer grain filling duration, better fruit flavor, larger fruit / vegetable size, shoot resistance and reduced accommodation.
[00175] Increased yield, referring to total biomass per hectare, yield per hectare, grain / fruit weight, seed size and / or hectoliter weight as well as product quality increase, including: improved processing related to the distribution of size (grain, fruit, etc.), homogeneous ripening, grain moisture, better grinding, better vinification, better preparation, increased juice yield, harvest, digestibility, sedimentation value, fall time, pod stability, stability of storage, improvement in fiber length / strength / uniformity, increase in milk and / or satisfaction of the quality of animals fed with silage, adaptation to cooking (cooking and frying); also including improvement in terms of the market in terms of improving the quality of the fruit / grain, size distribution (grain, fruit, etc.), increasing storage capacity / shelf life, firmness / smoothness, flavor (aroma, texture, etc. .), degree (size, shape, number of grains, etc.), number of grains / fruits per branch, crispy, freshness, covering with wax, frequency of physiological dysfunctions, color, etc. further including increasing the desired ingredients, such as, e.g. protein content, fatty acids, oil content, oil quality, amino acid composition, sugar content, acidity content (pH), sugar / acidity ratio (Brix), polyphenols, starch content, nutritional quality, content / index gluten, energy content, flavor, etc. and also including reduction of unwanted ingredients, such as, e.g. less mycotoxins, less aflatoxins, geosmin level, phenolic aromas, polyphenol oxidases and peroxidases, nitrate content, etc.
[00176] Sustainable agriculture, including efficiency in the use of the nutrient, mainly efficiency in the use of nitrogen (N), efficiency in the use of phosphorus (P), efficiency in the use of water, improved perspiration, respiration and / or assimilation rate of CO2, better nodulation, improved Ca metabolism, etc.
[00177] Delay in senescence, including improvement in plant physiology, which manifests itself, for example, in a longer grain filling phase, which gives rise to greater yield, longer duration of the green coloring of the plant leaf and , thus, including color (greening), water content, dryness, etc. Consequently, in the context of the present invention, it has been found that the specific patent application for the invention of the combination of the active compound makes it possible to prolong the duration of the green area of the leaf, which delays the maturation (senescence) of the plant. The main advantage for the farmer is a longer grain filling phase which gives rise to a higher yield. There is also an advantage for the farmer on the basis of greater flexibility in terms of harvest time.
[00178] In this way, "sedimentation value" is a measure of protein quality and describes, according to Zeleny (Zeleny value) the degree of sedimentation of suspended flour in a lactic acid solution during a standard time interval . This is assumed to be a measure of cooking quality. The increase in the gluten fraction of the flour in the lactic acid solution affects the sedimentation rate of a flour suspension. Higher gluten content and better gluten quality lead to slower sedimentation and higher values in the Zeleny test. The sedimentation value of the flour depends on the composition of the wheat protein and is most often correlated with the protein content, stiffness of the wheat and the volume of the container and breads. A stronger correlation between bread volume and Zeleny sedimentation volume compared to the SDS sedimentation volume could be due to the protein content that influences the Zeleny volume and value (Czech J. Food Sci. Vol. 21, N 3: 91-96, 2000).
[00179] Furthermore, the "fall time" as mentioned above is a measure for the cooking quality of cereals, especially wheat. The drop time test indicates that the shoot may have been damaged. This means changes have already occurred to the physical characteristics of the starch portion of the wheat grain. In this way, the drop time instrument analyzes the viscosity by measuring the resistance of a flour and water paste to a drop plunger. The time (in seconds) for this to happen is known as the down time. The fall time results are recorded as an index of enzyme activity in a wheat or flour sample and the results are expressed in time as seconds. A high drop time (for example, above 300 seconds) indicates minimal enzyme activity and good quality wheat or flour. A low drop time (for example, less than 250 seconds) indicates substantial enzyme activity and wheat damaged by sprouts or flour.
[00180] The term "more developed root system" / "improved root growth" refers to a longer root system, deeper root growth, faster root growth, higher root dehydration / fresh weight , higher root volume, larger root surface area, larger root diameter, higher root stability, greater root branching, greater number of root hairs, and / or more root tips and can be measured by analyzing the root architecture using appropriate methodologies and image analysis programs (eg WinRhizo).
[00181] The term "efficiency of water use in culture" refers technically to the mass of agricultural production per unit of water consumed and economically to the value of product (s) produced per unit of volume of water and can, for ex. be measured in terms of yield per ha, plant biomass, thousand grain mass (KTW) and number of ears per m2.
[00182] The term "efficiency of nitrogen utilization" technically refers to the mass of agricultural production per unit of nitrogen consumed and economically to the value of product (s) produced per unit of nitrogen consumed, reflecting absorption and utilization efficiency .
[00183] Improvement of the greening / improvement of the color and improvement of the photosynthetic efficiency as well as the senescence delay can be measured by means of well-known techniques, such as a HandyPea system (Hansatech). Fv / Fm is a parameter widely used to indicate the maximum quantum efficiency of photosystem II (PSII). This parameter is highly regarded as a selective indication of the photosynthetic performance of the plant with healthy samples typically reaching a maximum Fv / Fm value of approximately 0.85. Values lower than that referred to will be observed if a sample is exposed to some type of biotic or abiotic stress that has reduced the capacity of photochemical interruption of energy within PSII. Fv / Fm is presented as a variable fluorescence ratio (Fv) over the maximum fluorescence value (Fm). The Performance Index is essentially an indicator of the sample's vitality. (See eg Advanced Techniques in Soil Microbiology, 2007, 11, 319-341; Applied Soil Ecology, 2000, 15, 169-182.)
[00184] The improvement in greening / improved color and improved photosynthetic efficiency as well as the delay in senescence can also be assessed by measuring the gross photosynthetic rate (Pn), by measuring the chlorophyll content, e.g. by the method of Ziegler and Ehle, by measuring photochemical efficiency (Fv / Fm ratio), by determining shoot growth and final root and / or crown biomass, by determining cane density as well as root mortality.
[00185] Within the context of the present invention, preference is given to improving the physiological effects of the plant, which are selected from the group that includes: increased root growth / more developed root system, improved greening, improved efficiency of use of water (correlating reduced water consumption), improvement in the efficiency of nutrient use, including mainly the improvement in the efficiency of nitrogen (N) utilization, delayed senescence and increased yield.
[00186] Within the increase in yield, preference is given to an improvement in the sedimentation value and the fall time as well as to an improvement in protein and sugar content - mainly with plants selected from the cereal group (preferably wheat).
[00187] Preferably the new use of the fungicidal compositions of the present invention refers to a combined use of a) preventive and / or curative control of pathogenic and / or nematode fungi, with or without resistance management and b) at least growth increase root, improvement in greening, improvement in water use efficiency, senescence delay and increased yield. From group b) the increase in the root system, efficiency in the use of water and efficiency in the use of N. are particularly preferred. Seed Treatment
[00188] The invention further includes a method for treating the seed. The invention also relates to the seed that was treated by one of the methods described in the previous paragraph. The seeds of the invention are employed in methods to protect the seed from harmful microorganisms. In these methods, the seed treated with at least one active ingredient of the invention is used.
[00189] The mixtures or compositions of the invention are also suitable for treating the seed. A large part of the damage to crop plants caused by harmful organisms is triggered by infection of the seed during storage or after sowing and also during and after germination of the plant. The stage is particularly critical, since the roots and shoots of the growing plant are particularly sensitive and even minimal damage can result in the death of the plant. There is, therefore, a great interest in protecting the seed and the plant to germinate using appropriate compositions.
[00190] The control of phytopathogenic fungi when treating plant seeds has been known for a long time and is the subject of constant improvements. However, seed treatment involves a number of problems which cannot always be satisfactorily solved. For example, it is desirable to develop methods to protect the germinating seed and plant, which dispenses with, or at least significantly reduces, the additional application of crop protection compositions after planting or after plant appearance. It is also desirable to optimize the amount of the active ingredient used in order to provide the best possible protection for the seed and plant to germinate against attacks by phytopathogenic fungi, but without damaging the plant itself with the active ingredient employed. In particular, seed treatment methods should also consider the intrinsic fungicidal properties of transgenic plants in order to obtain optimum protection for the seed and the plant that is germinating with minimal consumption of crop protection compositions.
[00191] The present invention therefore also relates to a method for protecting the germinating seed and plants from counterattacks by phytopathogenic fungi, treating the seed with a composition of the invention. The invention also relates to the use of compositions of the invention for treating seed to protect the seed and plant from germinating phytopathogenic fungi. The invention also relates to the seed that has been treated with a composition of the invention for protection against phytopathogenic fungi.
[00192] The control of phytopathogenic fungi that damage plants after emergence is carried out primarily by treating the soil and above-ground parts of plants with crop protection compositions. Due to concerns about the possible influence of crop protection compositions on the environment and health of humans and animals, efforts are made to reduce the active ingredients applied.
[00193] One of the advantages of the present invention is that the particular systemic characteristics of the mixtures or compositions of the invention mean that the treatment of the seed with these mixtures and compositions not only protects the seed itself, but also the plants resulting after emergence, from phytopathogenic fungi and pests. In this way, immediate treatment of the crop at the moment of sowing or right after it can be dispensed with.
[00194] It is also considered advantageous that the mixtures or compositions of the invention can be used mainly with transgenic seed, in which case the plant that grows from this seed has the capacity to express a protein that acts against pests. Because of the treatment of such seed with the mixtures or compositions of the invention, only the expression of the protein, for example an insecticidal protein, can control certain pests. Surprisingly, another synergistic effect can be seen in this case, which further increases the effectiveness in protecting against pest attacks.
[00195] The compositions of the invention are suitable to protect the seed from any variety of plant that is used in agriculture, greenhouses, forests or horticulture and wine growing. In particular, this is the seed of cereals (such as wheat, barley, rye, triticale, sorghum / mildew and oats), corn, cotton, soybeans, rice, potatoes, sunflowers, beans, coffee, beets (for example, beets saccharin and fodder beet), peanuts, rapeseed, poppy, olives, coconut, cocoa, sugar cane, tobacco, vegetables (such as tomatoes, cucumbers, onions and lettuce), lawns and ornamental plants (see below). The treatment of cereal seed (such as wheat, barley, rye, triticale and oats), corn and rice is of particular importance. Soya beans are particularly preferred.
[00196] As described below, the treatment of transgenic seed with the mixtures or compositions of the invention is of particular importance. This refers to the seed of plants that contain at least one heterologous gene that allows the expression of a polypeptide or protein with insecticidal characteristics. The heterologous gene in the transgenic seed may originate, for example, in a microorganism of the species Bacillus, Rhizobium, Pseudomonas,
[00197] Serratia, Trichoderma, Clavibacter, Glomus or Gliocladium. The heterologous gene originates preferentially in Bacillus sp., In which case the gene product is effective against the European corn caterpillar and / or chrysomelid of the corn root system. Most preferably, the heterologous gene originates from Bacillus thuringiensis.
[00198] In the context of the present invention, the composition of the invention is applied to the seed alone or in a suitable formulation.
[00199] Preferably, the seed is treated in a state in which it is stable enough so that no damage occurs in the course of treatment. In general, the seed can be treated at any time between harvest and sowing. It is usual to use the seed that has been separated from the plant and freed from ears, peels, cuttings, lining, hair or flesh of the fruits. For example, it is possible to use the seed that has been harvested, cleaned and dried to a moisture content of less than 15% by weight. Alternatively, it is possible to use the seed which, after drying, for example, was treated with water and then dried again.
[00200] When treating the seed, care must be taken and consider that the amount of the composition of the invention applied to the seed and / or the amount of other additives is selected in such a way that the germination of the seed is not harmed or that the plant from there resultant is not damaged. This is an aspect to keep in mind, particularly in the case of active ingredients that can have phytotoxic effects at certain rates of application.
[00201] The compositions of the present invention can be applied directly, that is, without containing any other components and without having been diluted. In general it is preferable to apply the compositions to the seed in the form of suitable formulations. Suitable formulations and seed treatment methods are known to those skilled in the art and are described, for example, in the following documents: US 4,272,417, US 4,245,432, US 4,808,430, US 5,876,739, US 2003/0176428 A1, WO 2002/080675, WO 2002/028186.
[00202] Mixtures or compositions usable according to the invention can be converted to the usual seed coating formulations, such as solutions, emulsions, suspensions, powders, foams, sludges or other coating compositions for the seed and also formulations ULV.
[00203] These formulations are prepared in a known way, mixing the active ingredients or mixtures with the usual additives, for example, usual extenders and also solvents and diluents, dyes, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners, adhesives, sable and also water.
[00204] Useful dyes that may be present in seed coating formulations usable according to the invention are all dyes that are normally used for this purpose. It is possible to use pigments, which are poorly soluble in water or dyes that are water-soluble. Examples include the dyes known by the names of Rhodamine B, C.I. Pigment red 112 and C.I. Red solvent 1.
[00205] Useful wetting agents that can be present in seed coating formulations usable according to the invention are all substances that promote wetting and that are conventionally used for the formulation of active agrochemical ingredients. Preference is given to the use of alkylnaphthalenesulfonates, such as diisopropyl or diisobutylnaphthalenesulfonates.
[00206] Useful dispersing and / or emulsifying agents that may be present in seed coating formulations usable according to the invention are all nonionic, anionic and cationic dispersants that are conventionally used for the formulation of active agrochemical ingredients. Preference is given to the use of nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants. Suitable non-ionic dispersants mainly include blocking polymers of ethylene oxide / propylene oxide, alkylphenol polyglycolic ethers and tristylphenol polyglycolic ethers and the corresponding phosphated or sulfated derivatives. Suitable anionic dispersants are mainly lignosulfonates, polyacrylic acid salts and arylsulfonate / formaldehyde condensates.
[00207] Defoamers which may be present in seed coating formulations usable according to the invention are all foaming inhibiting substances that are conventionally used for the formulation of active agrochemical ingredients. Silicone defoamers and magnesium stearate can be used preferably.
[00208] The preservatives that may be present in seed coating formulations usable according to the invention are all substances used for this purpose in agrochemical compositions. As an example, dichlorophene and benzylhemiformal alcohol can be mentioned.
[00209] Secondary thickeners that may be present in seed coating formulations usable according to the invention are all substances used for this purpose in agrochemical compositions. Preferred examples include cellulose derivatives, acrylic acid derivatives, xanthan gum, modified clays and finely divided silica.
[00210] Adhesives which may be present in seed coating formulations usable according to the invention include all binders usable in seed coating products.
[00211] Polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tilase can be cited as preferred.
[00212] The gibberellins which may be present in the seed coating formulations usable according to the invention may preferably be all gibberellins A1, A3 (= gibberellic acid), A4 and A7, with particular preference being given to the use of gibberellic acid. Gibberellins are known (cf. R. Wegler "Chemie der Pflanzenschutz- und Schadlingsbekampfungsmittel" [Chemistry of the Crop Protection Compositions and Pesticides], vol. 2, Springer Verlag, 1970, p. 401-412).
[00213] Seed coating formulations usable according to the invention can be used directly or after having been previously diluted with water, for the treatment of a wide range of different seeds, including the seed of transgenic plants. In this case, additional synergistic effects may also occur in the interaction with the substances formed by expression.
[00214] For the treatment of the seed with the seed coating formulations usable according to the invention, or the preparations prepared therefrom by adding water, all the mixed units usable for the seed coating are useful. Specifically, the procedure in the seed coating is to place the seed in a mixer, to add the particular desired amount of seed coating formulations, as such or after previous dilution with water and to mix everything until the formulation is homogeneously distributed in the seed. If appropriate, this procedure is followed by a drying process. Mycotoxins
[00215] Furthermore, the treatment of the invention can reduce the mycotoxin content in the harvested material and the food can be prepared from it. Mycotoxins include, but are not limited to, the following: deoxynivalenol (DON), nivalenol, 15-Ac-DON, 3-Ac-DON, T2- and HT2toxin, fumonisins, zearalenone, moniliformine, fusarin, diaceotoxiscirpenol (DAS) , beauvericina, eniatina, fusaroproliferina, fusarenol, ocratoxinas, patulina, ergot alkaloids and aflatoxins that can be produced, for example, by the following fungi: Fusarium species., such as F. acuminatum, F. asiaticum, F. avenaceum, F. crookwellense, F. culmorum, F. graminearum (Gibberella zeae), F. equiseti, F. fujikoroi, F. musarum, F. oxysporum, F. proliferatum, F. poae, F. pseudograminearum, F. sambucinum, F. scirpi, F. semitectum, F. solani, F. sporotrichoides, F. langsethiae, F. subglutinans, F. tricinctum, F. verticillioides etc., and also by Aspergillus spec., Such as A. flavus, A. parasiticus, A. nomius , A. ochraceus, A. clavatus, A. terreus, A. versicolor, Penicillium spec., Such as P. verrucosum, P. viridicatum, P. citrinum, P. expansum, P. claviforme, P. roqueforti, Claviceps spec., such as C. purpurea, C. fusiformis, C. paspali, C. africana, Stachybotrys species and others. Material Protection
[00216] Mixtures or compositions or compositions can also be used in the protection of materials, for the protection of industrial materials against attacks and destruction by harmful microorganisms, for example, fungi and insects.
[00217] In addition, mixtures or compositions can be used as antifouling compositions, alone or in combinations with other active ingredients.
[00218] Industrial materials in the present context mean inanimate materials that have been prepared for use in industry. For example, industrial materials that must be protected by the mixtures or compositions of the invention from microbiological alteration or destruction, can be adhesives, glues, paper, wallpaper, boards, cardboard, textiles, carpets, leather, wood, fibers and fabrics, paints and plastic articles, coolant lubricants and other materials that can be infected or destroyed by microorganisms. Parts of manufacturing facilities and buildings, for example, refrigeration circuits, cooling and heating systems, and ventilation and air conditioning units, which can be negatively affected by the proliferation of microorganisms, can also be mentioned within the context of the materials to be protected. Industrial materials within the context of the present invention preferably include adhesives, sizes, paper and board, leather, wood, paints, cooling lubricants and heat transfer fluids, more preferably wood.
[00219] The mixtures or compositions of the invention can prevent adverse effects, such as decay, decay, discoloration or mold formation.
[00220] In the case of wood treatment, the compounds / compositions according to the invention, can also be used against fungal diseases that can develop in or inside the wood. The term "wood" means all types of wood and all types of work done with this wood intended for construction, for example, solid wood, high-density wood, laminated and plywood. The method for treating wood according to the invention consists mainly of contacting one or more compounds according to the invention, or a composition according to the invention, including, for example, direct application, spraying, dipping, injection or any other suitable means. The method for treating wood, according to the invention, consists mainly of contact with one or more compounds of the present invention, or a composition according to the invention, including, for example, direct application , spraying, immersion, injection or any other suitable means.
[00221] In addition, the compounds of the invention can be used to protect objects, which come into contact with salt water or brackish water, especially hulls, screens, nets, buildings, ropes and signaling systems, cooling.
[00222] The method of the invention for controlling harmful fungi can also be employed to protect stored goods. Stored goods mean natural substances of plant or animal origin or processed products thereof and which are of natural origin and for which long-term protection is sought. Stored goods of plant origin, for example, plants or parts of plants, such as stems, leaves, tubers, seeds, fruits, grains, can be protected as soon as they are finished harvesting or after processing by (pre) drying, humidification, fragmentation, grinding, pressure or cooking. The well-stored ones also include unprocessed wood, such as construction wood, electricity poles and barriers or in the form of a final product, such as furniture. Stored goods of animal origin are, for example, leather, leather, fur and fur. Mixtures or compositions of the invention can prevent adverse effects, such as decay, decay, discoloration or mold formation.
[00223] Microorganisms capable of degrading or altering industrial materials include, for example, bacteria, fungi, yeasts, algae and sludge organisms. The mixtures or compositions of the invention preferably act against fungi, especially molds, fungi that discolor wood and destroy wood (Ascomycetes, Basidiomycetes, Deuteromycetes and Zygomycetes), and against sludge and algae organisms. Examples include microorganisms of the following genera: Alternaria, such as Alternaria tenuis; Aspergillus, such as Aspergillus niger; Chaetomium, such as Chaetomium globosum; Coniophora, such as Coniophora puetana; Lentinus, such as Lentinus tigrinus; Penicillium, such as Penicillium glaucum; Polyporus, such as Polyporus versicolor; Aureobasidium, such as Aureobasidium pullulans; Sclerophoma, such as Sclerophoma pityophila; Trichoderma, such as Trichoderma viride; Ophiostoma spp., Ceratocystis spp., Humicola spp., Petriella spp., Trichurus spp., Coriolus spp., Gloeophyllum spp., Pleurotus spp., Poria spp., Serpula spp. and Tyromyces spp., Cladosporium spp., Paecilamyces spp. Mucor spp., Escherichia, such as Escherichia coli; Pseudomonas, such as Pseudomonas aeruginosa; Staphylococcus, such as Staphylococcus aureus, Candida spp. and Saccharomyces spp., such as Saccharomyces cerevisae. Antimycotic Activity
[00224] Furthermore, the mixtures or compositions of the invention also have very good antimycotic activity. They have a very wide spectrum of antimycotic action, mainly against dermatophytes and yeasts, molds and diphasic fungi (for example against Candida species, such as C. albicans, C. glabrata) and Epidermophyton floccosum, Aspergillus species such as A. niger and A. fumigatus, Trichophyton species, such as T. mentagrophytes, Microsporon species, such as M. canis and M. audouinii. This list of funds is by no means a restriction on the mycotic spectrum covered and is merely illustrative.
[00225] The mixtures or compositions of the invention can therefore be used in medical and non-medical applications. Genetically modified organisms
[00226] As mentioned above, it is possible to treat all plants and their parts according to the invention in a preferred embodiment, plant species and cultivars are treated, or those obtained through conventional biological culture methods, such as crossing or fusion of protoplasts and also parts thereof. In a further preferred embodiment, transgenic plants and cultivars obtained by means of genetic engineering methods are treated, if appropriate in combination with conventional methods (genetically modified organisms) and parts thereof. The term "parts" or "parts of plants" has already been clarified above. More preferably, the plants of the cultivars, each commercially available or in use, are treated in accordance with the invention. It is understood that the cultivars designate plants with new properties ("characteristics") and that they were obtained by conventional culture, by mutagenesis or by recombinant DNA techniques. They can be cultivars, varieties, biotypes or genotypes.
[00227] The treatment method according to the invention can be used in the treatment of genetically modified organisms (OMGs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants in which a heterologous gene has been stably integrated. The term "heterologous gene" essentially means a gene that is supplied or installed outside the plant and when introduced into the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic properties or others through the expression of a protein or polypeptide of interest or through downward regulation or silencing of other gene (s) that are present in the plant (using, for example, antisense technology, cosupressure technology, ARN - ARNi interference technology or microRNA technology - miRNA technology)). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its specific location in the plant's genome is called a transgenic transformation or event.
[00228] Depending on the species of plant or cultivar, its location and growing conditions (soil, climate, vegetation period, diet), the treatment according to the invention can also result in superaddition ("synergistic") effects . Thus, for example, it is possible to reduce application rates and / or widen the activity spectrum and / or increase the activity of the active compounds and compositions that can be used according to the invention, better plant development, greater temperature tolerance high or low, greater tolerance to drought or water or salt content in the soil, greater flowering capacity, ease of harvest, accelerated ripening, greater yield of harvest, larger fruits, greater plant height, greener leaves, early flowering, higher quality and / or greater nutritional value of the harvest products, greater concentration of sugar in the fruits, greater stability in storage and / or ease of processing the harvested products, exceeding what was expected.
[00229] At certain application rates, combinations of active compound according to the invention can also have a strengthening effect on plants. Therefore, they are also suitable for mobilizing the plant's defense system against attacks by harmful microorganisms. If appropriate, it may be one of the reasons for the greater activity of the combinations according to the invention, for example against fungi. Substances for plant strengthening (resistance induction) are, in the current context, understood as those substances or combinations of substances that have the capacity to stimulate the defense system of plants, such that when subsequently inoculated with harmful microorganisms, the Treated plants show a substantial degree of resistance to these microorganisms. In the present case, harmful microorganisms mean phytopathogenic fungi, bacteria and viruses. In this way, the substances according to the invention can be used to protect plants against attack by the pathogens mentioned above for a certain period of time after treatment. The period of time during which the protection is effective, normally extends from 1 to 10 days, preferably from 1 to 7 days after the treatment of the plants with the active compounds.
[00230] Plants and cultivars to be treated preferably according to the invention include all plants that have genetic material that confers particularly advantageous characteristics, useful for these plants (whether obtained by culture and / or biotechnology).
[00231] Plants and cultivars that are also preferably treated according to the invention are resistant to one or more foci of biotic stress, that is, the said plants show to have better defenses against animal and microbial pests, such as against nematodes, insects, arachnids, fungi, bacteria, viruses and / or phytopathogenic viroids.
[00232] Examples of plants resistant to nematodes and insects are described, e.g. in US 11 / 765,491, US 11 / 765,494, US 10 / 926,819, US 10 / 782,020, US 12 / 032,479, US 10 / 783,417, US 10 / 782,096, US 11 / 657,964, US 12 / 192,904, US 11 / 396,808, US 11 / 396,808 , US 12 / 166,253, US 12 / 166,239, US 12 / 166,124, US 12 / 166,209, US 11 / 762,886, US 12 / 364,335, US 11 / 763,947, US 12 / 252,453, US 12 / 209,354, US 12 / 209,354, US 12 / 491,396 , US 12 / 497,221, US 12 / 644,632, US 12 / 646,004, US 12 / 701,058, US 12 / 718,059, US 12 / 721,595 and US 12 / 638,591.
[00233] Plants and cultivars, which can also be treated according to the invention are those plants that are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, exposure to low temperatures, exposure to high temperatures, osmotic stress, floods, high salt content in the soil, increased mineral exposure, exposure to ozone, limited availability of nitrogen nutrients, availability limited amount of phosphorus nutrients, avoid shade.
[00234] Plants and cultivars, which can also be treated according to the invention are those plants characterized by enhanced yield characteristics. The higher yield in these plants may be the result of, for example, optimized plant physiology, growth and development, such as efficacy in water use, efficacy in water retention, optimized nitrogen use, enhanced carbon assimilation, better photosynthesis, greater efficiency in germination and accelerated maturation. Yield can also be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to early flowering, control of flowering for hybrid seed production, seedling vigor, plant size, internode, number and distance, root growth, seed size, fruit size, pod size, number of pods or ears, number of seeds per pod or ear, Seed mass, enhanced seed filling, reduced seed dispersion, reduced dehiscence of pod and deposit resistance. Other yield characteristics include the composition of the seed, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritive compounds, better processing and better storage stability.
[00235] The plants that can be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor, which results in a yield, vigor, health and resistance against biotic and abiotic stress spots generally superior. These plants are typically produced by crossing a pure sterile male parent line (female parent) with another pure fertile male parent line (male parent). Hybrid seed is usually harvested from male sterile plants and sold to producers. Sterile male plants can sometimes (eg maize) be produced by cutting the male flower's panicle, but more typically, male sterility can be the result of genetic determinants in the plant's genome. In that case, and especially when the seed is the product to be harvested from hybrid plants, it is typically useful to ensure that male fertility in hybrid plants is fully restored. This can be achieved by ensuring that the male ascendant has appropriate fertility restoring genes capable of restoring male fertility in hybrid plants that contain the genetic determinants responsible for male sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) have, for example, been described in Brassica species (W0 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and US 6,229,072). However, the genetic determinants for male sterility may also be located in the nuclear genome. Sterile male plants can also be obtained by plant biotechnological methods, such as genetic engineering. A particularly useful means of obtaining male sterile plants is described in WO 89/10396, in which, for example, a ribonuclease, such as barnase, is selectively expressed in stamen cells. Fertility can be restored by expression in the tapetum cells of an inhibitor such as a barstar (eg WO 91/02069).
[00236] Plants or cultivars (obtained by biotechnological methods of plants, such as genetic engineering), which can be treated according to the invention are plants tolerant to herbicides, that is, plants made tolerant to one or more specific herbicides. These plants can be obtained by genetic transformation or by selecting plants that contain a mutation that gives this tolerance to herbicides.
[00237] Herbicide resistant plants are, for example, glyphosate tolerant plants, i.e. plants made tolerant to the glyphosate herbicide or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of these EPSPs genes are the AroA gene (CT7 mutant) from the bacterium Salmonella tifimurium (Science 1983, 221, 370-371), the CP4 gene from the bacterium Agrobacterium sp. (Curr. Topics Plant Physiol. 1992, 7, 139-145), the genes encoding an EPSPS from Petunia (Science 1986, 233, 478-481), an EPSPS from Tomato (J. Biol. Chem. 1988, 263, 4280-4289), or an EPSPS from Eleusina (WO 01/66704). It can also be a mutated EPSPE enzyme, as described, for example, in EP 0837944, WO 00/66746, WO 00/66747 or WO02 / 26995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme, as described in US 5,776,760 and US 5,463,175. Glyphosate tolerant plants can also be obtained by expression of a gene encoding a glyphosate acetyltransferase enzyme, as described in WO 02/036782, WO 03/092360, WO 2005/012515 and WO 2007/024782. Glyphosate-tolerant plants can also be obtained by selecting plants that contain natural mutations of the genes referred to, as described, for example, in WO 01/024615 or WO 03/013226. Plants that express the EPSPS genes that confer glyphosate tolerance are described, for example, in US 11 / 517,991, US 10 / 739,610, US 12 / 139,408, US 12 / 352,532, US 11 / 312,866, US 11 / 315,678 , US 12 / 421,292, US 11 / 400,598, US 11 / 651,752, US 11 / 681,285, US 11 / 605,824, US 12 / 468,205, US 11 / 760,570, US 11 / 762,526, US 11 / 769,327, US 11 / 769,255, US 11 / 769,255 , US 11/943801 or US 12 / 362,774. Plants that comprise other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in US 11 / 588,811, US 11 / 185,342, US 12 / 364,724, US 11 / 185,560 or US 12 / 423,926.
[00238] Other herbicide-resistant plants are, for example, plants that are made tolerant to herbicides by inhibiting the enzyme glutamine synthase, such as bialafos, phosphinothricin or glufosinate. These plants can be obtained by expressing an herbicide detoxifying enzyme or a mutant glutamine synthase enzyme that is resistant to inhibition, e.g., described in US 11 / 760,602. Such an effective detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein of the Streptomyces species). Plants that express a phosphinothricin acetyltransferase enzyme are, for example, described in US 5,561,236; US 5,648,477; US 5,646,024; US 5,273,894; US 5,637,489; US 5,276,268; US 5,739,082; US 5,908,810 and US 7,112,665.
[00239] Other herbicide tolerant plants are also plants that are made tolerant to the hydroxyphenylpyruvatedoxygenase enzyme (HPPD) inhibiting herbicides. HPPD is an enzyme that catalyzes the reaction in which parahydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD inhibitors can be transformed with a gene encoding a natural resistant HPPD enzyme or a gene encoding a mutated or chimeric HPPD enzyme, as described in WO 96/38567, WO 99/24585, WO 99/24586, WO 09/144079, WO 02/046387, or in US 6,768,044. Tolerance to HPPD inhibitors can also be obtained by transforming plants with genes encoding certain enzymes that make it possible to form homogenates despite the inhibition of the native HPPD enzyme by the HPPD inhibitor. These plants and genes are described in WO 99/34008 and WO 02/36787. Plant tolerance to HPPD inhibitors can further be improved by transforming plants with a gene encoding an enzyme with a prefenate dehydrogenase (PDH) activity in addition to a gene encoding an HPPD tolerant enzyme, as described in WO 04/024928. Other plants can be made more tolerant to HPPD-inhibiting herbicides by adding to their genome an gene encoding an enzyme capable of metabolizing or degrading HPPD-inhibitors, such as the CYP450 enzymes shown in WO 2007/103567 and WO 2008/150473.
[00240] Still other plants resistant to herbicides are plants that are made tolerant to acetolactatosintase (ALS) inhibitors. Known ALS inhibitors include, for example, sulfonylurea herbicides, imidazolinone, triazolopyrimidines, priimidinioxy (thio) benzoates, and / or sulfonylaminocarbonyltriazolinone. It is known that the different mutations of the ALS enzyme (also known as acetoxy hydroxyacid synthase, AHAS) confer tolerance to different herbicides and groups of herbicides, as described, for example, in Tranel and Wright (Weed Science 2002, 50, 700-712), but also, in US 5,605,011, US 5,378,824, US 5,141,870, and US 5,013,659. The production of plants tolerant to sulfonylurea and plants tolerant to imidazolinone is described in US 5,605,011; US 5,013,659; US 5,141,870; US 5,767,361; US 5,731,180; US 5,304,732; US 4,761,373; US 5,331,107; US 5,928,937; and US 5,378,824 and WO 96/33270.
[00241] Other imidazolinone tolerant plants are also described, for example in WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006 / 024351 and
[00242] WO 2006/060634. Other sulfonylurea and imidazolinone tolerant plants are also described, for example, in WO 2007/024782 and US 61/288958.
[00243] Other plants tolerant to imidazolinones and / or sulfonylurea and / or sulfamoylcarbonyltriazolinones, can be obtained by induced mutagenesis, by selection in cell cultures in the presence of the herbicide or culture of mutations as described, for example, for soy in US 5,084,082, for rice in WO 97/41218, for sugar beet, in US 5,773,702 and in WO 99/057965, for lettuce in US 5,198,599, or for sunflower in WO 01/065922.
[00244] The plants and cultivars (obtained by biotechnology methods applied to plants such as genetic engineering) that can also be treated according to the invention are transgenic plants resistant to insects, that is, plants made resistant to invasions by certain target insects . These plants can be obtained by means of genetic transformation or by selecting plants containing a mutation that confers this resistance to insects.
[00245] A "insect resistant plant", as currently used, includes any plant that contains at least one transgene that includes a coding sequence that encodes: a Bacillus thuringiensis crystal insecticidal protein or an insecticidal portion thereof, such as the insecticidal crystal proteins indicated by Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62: 807-813), updated by Crickmore et al. (2005) in the nomenclature of the Bacillus thuringiensis toxin, online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, eg proteins of the Cry protein classes : Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3A or Cry3Bb or insecticidal portions thereof (eg EP-A 1 999 141 and WO 2007/107302), or those proteins encoded by synthetic genes like, eg ., described in US 12 / 249,016; or a Bacillus thuringiensis protein crystal or a portion of it that is insecticidal in the presence of a second Bacillus thuringiensis protein crystal or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 protein crystals (Nat. Biotechnol. 2001 , 19, 668-72; Applied Environm. Microbiol. 2006, 71, 1765-1774) or the binary toxin composed of the Cry1A or Cry1F proteins and the Cry2A or Cry2Ab or Cry2Ae proteins (US 12 / 214,022 and EP-A 2,300,618); or an insecticidal protein comprising parts of different crystals of Bacillus thuringiensis insecticidal protein, such as a hybrid of 1) above or a hybrid of the above 2) proteins, e.g. the Cry1A.105 protein produced by the MON89034 corn event (WO 2007/027777); or 4) a protein from any of the previous paragraphs 1) to 3), in which some amino acids, particularly amino acids 1 to 10 have been replaced by another amino acid to obtain greater insecticidal activity against a specific species of insects and / or to expand the spectrum of target insect species affected and / or because the changes introduced in the DNA coding during cloning or transformation, such as the Cry3Bb1 protein in the MON863 or MON88017 corn events, or the Cry3A protein in the MIR604 corn event; or 5) insecticidal protein secreted from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as vegetative insecticidal (VIP) proteins listed at: http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/ vip.html, eg proteins of the VIP3A protein class; or a secreted protein from Bacillus thuringiensis or Bacillus cereus that is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or a hybrid insecticidal protein comprising parts of different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of 1) anterior or a hybrid of the proteins of 2) anterior; or a protein of any of the previous paragraphs 5) to 7), in which some amino acids, particularly amino acids 1 to 10 have been replaced by another amino acid to obtain greater insecticidal activity against a specific species of insects and / or to expand the spectrum of target insect species affected and / or because the changes introduced in the DNA encoding during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3A protein in the COT102 cotton event; or a protein secreted from Bacillus thuringiensis or Bacillus cereus that is insecticidal in the presence of a crystal of Bacillus thuringiensis protein, such as the binary toxin consisting of VIP3 and Cry1A (in US 61/126083 and US 61/195019) or the binary toxin consisting of the VIP3 protein and the Cry2A or Cry2Ab or Cry2Ae proteins (US 12 / 214,022 and EP-A 2 300 618). a previous 9) protein in which some amino acids, particularly amino acids 1 to 10 have been replaced by another amino acid to obtain greater insecticidal activity against a specific insect species and / or to expand the spectrum of affected target insect species and / or because the changes introduced in DNA coding during cloning or transformation (while still encoding an insecticidal protein)
[00246] Of course, a transgenic plant resistant to insects, as currently used, also includes any plant that includes a combination of genes encoding proteins in any of the previous classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein from any of the previous classes 1 to 10, to expand the spectrum of the target insect species affected by using different proteins directed against different target insect species or to delay the development of insect resistance to plants using different insecticidal proteins against the same target insect species but with different modes of action, such as binding to different receptor binding sites in the insect.
[00247] A "transgenic insect resistant plant", as currently used, also includes any plant that contains at least one transgene that includes a sequence that, by expression, produces a double-stranded RNA which after ingestion by a insect pest on the plant inhibits the growth of this insect pest as described, e.g. in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.
[00248] Plants or cultivars (obtained by biotechnological methods of plants, such as genetic engineering), which can also be treated according to the invention are tolerant to abiotic stresses. These plants can be obtained by means of genetic transformation or by selecting plants containing a mutation that confers that resistance to stress.
[00249] In particular, useful stress-tolerant plants include: plants containing a transgene capable of reducing the expression and / or activity of the poly (ADO-ribose) polymerase (PARP) gene in plant cells or plants, as described in WO 00/04173, WO / 2006/045633, EP-A 1,807,519 or EP-A 2,018,431. plants containing a stress tolerance-enhancing transgene, capable of reducing the expression and / or activity of PARG genes encoding plants and plant cells, as described, for example, in WO 2004/090140. plants containing a stress tolerance-enhancing transgene encoding a plant functional enzyme of the nicotineamide adenine dinucleotide synthesis pathway, including nicotinamidase, nicotinate phosphororibosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide described in, e.g. EP 1, WO 2006/133827, PCT / EP07 / 107326, EP-A 1,999,263 or WO 2007/107326.
[00250] Plants or cultivars (obtained by plant biotechnological methods, such as genetic engineering), which can also be treated according to the invention have modified quantity, quality and / or storage stability of the harvested products and / or altered characteristics specific ingredients of the harvested products, such as: transgenic plants that synthesize a modified starch, which presents changes in terms of physico-chemical characteristics, in particular the amylase content or the amylase / pectin ratio, the degree of ramifications, the length of medium chain, side chain distribution, viscosity behavior, gelling power, starch grain size and / or starch grain morphology, compared to starch synthesized in cells or wild plants, so that best suits special applications. Said transgenic plants that synthesize a modified starch are described, for example in EP-A 0 571 427, WO 95/04826, EP-A 0 719 338, WO 96/15248, WO 96/19581, WO 96/27674 WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO 99/58690 , WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860 , WO 04/056999, WO 05/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107 , WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, WO 2008/017518, WO 2008/080630, WO 2008/080631, EP 07090007.1, WO 2008/090008, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, US 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98 509, WO 2005/002359, US 5,824,790, US 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936, WO 2010/012796, WO 2010/003701, transgenic plants that synthesize non-starch carbohydrate polymers or that synthesize non-starch carbohydrate polymers with altered properties compared to wild plants without genetic modification. Examples are polyfructose-producing plants, especially of the inulin type and, as shown in EP-A 0,663,956, WO 96/01904, WO 96/21023, WO 98/39460 and WO 99/24593, plants producing alpha-1, 4glucans as presented in WO 95/31553, US 2002031826, US 6,284,479, US 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, alpha-1,6 branched alpha-1 producing plants , 4-glucans, as shown in WO 00/73422, alternating producing plants, as shown in, e.g. WO 00/47727, WO 00/73422, EP 06077301,7, US 5,908,975 and EP-A 0,728,213, transgenic plants that produce hyaluronan, as presented, for example, in WO 2006/032538, WO 2007/039315, WO 2007/039315 , WO 2007/039316, JP-A 2006-304779 and WO 2005/012529. transgenic plants or hybrid plants, such as onions with characteristics, such as "highly soluble solids content", "low degree of pungency" (BP) and / or "prolonged storage" (AP), as described in US 12 / 020,360 and US 61 / 054,026.
[00251] Plants and cultivars (which can be obtained by biotechnology methods applied to plants such as genetic engineering) which can also be treated according to the invention, such as cotton plant with altered fiber characteristics. These plants can be obtained by means of genetic transformation or by selecting plants containing a mutation that gives these characteristics to the fibers and include:
[00252] Plants, such as cotton plants, that contain an altered form of cellulose synthase genes, as described in WO 98/00549.
[00253] Plants, such as cotton plants, that contain an altered form of the homologous nucleic acids rsw2 or rsw3, as described in WO 2004/053219.
[00254] Plants, such as cotton plants, with greater expression of sucrose phosphate synthase, as described in WO 01/17333.
[00255] Plants, such as cotton plants, with enhanced expression of sucrose synthase, as described in WO 02/45485.
[00256] Plants, such as cotton plants, in which the plasmododematal propagation time at the base of the fiber cell is altered, for example, by selective fiber sub-regulation -1,3-glucanase, as described in WO 2005 / 017157, or as described in EP 2009/143995.
[00257] Plants, such as cotton plants, with fibers with altered reactivity, for example, through the expression of the N-acetylglucosaminatransferase gene including nodC and chitin synthase genes. As described in WO 2006/136351.
[00258] Plants and cultivars (which can be obtained by biotechnology methods applied to plants such as genetic engineering) which can also be treated according to the invention, such as oilseed rape or Brassica-related plants with oil profile characteristics changed. These plants can be obtained by means of genetic transformation or by selecting plants containing a mutation that gives these altered oil profile characteristics and include:
[00259] Plants, such as rapeseed plants, that produce oil or that have a high oleic acid content, as described, for example, in US 5,969,169, US 5,840,946 or US 6,323,392 or US 6,063,947.
[00260] Plants, such as rapeseed plants, that produce oil or that have a high content of linoleic acid, such as in US 6,270,828, US 6,169,190 or US 5,965,755.
[00261] Plants, such as rapeseed plants, that produce oil or that have a low level of saturated fatty acids, as described in US 5,434,283 or US 12/668303.
[00262] Plants and cultivars (which can be obtained by biotechnology methods applied to plants such as genetic engineering) which can also be treated according to the invention, such as flax plant, oilseed rape or Brassica related to dissemination characteristics of the seed. These plants can be obtained by means of genetic transformation or by selecting plants that contain a mutation that confers the said characteristics of seed dissemination and includes plants such as oilseed rape plants with delayed or reduced seed dissemination, as described in US 61 / 135,230, WO 2009/068313 and WO 2010/006732.
[00263] The plants and cultivars (which can be obtained by biotechnology methods applied to plants such as genetic engineering) that can also be treated according to the invention are plants, such as tobacco, modified post-transactional protein modification models, for example, as described in WO 2010/121818 and WO 2010/145846.
[00264] Transgenic plants that can be treated according to the invention, which contain transformation events or combinations of transformation events, which are subject to petitions by statute without regulation in the United States of America, with the "Animal and Plant Health Inspection Service "(APHIS) of the United States Department of Agriculture (USDA) whether granted or pending. This information is readily available at any time by APHIS (4700 River Road, Riverdale, MD 20737, USA), for example, on its website (URL http://www.aphis.usda.gov/brs/not_reg.html ). On the filing date of this application, petitions for unregulated status that were pending at APHIS or had been granted by APHIS are those that contain the following information:
[00265] Petition: Petition identification number. Technical descriptions of the transformation events can be found in the individual petition documents, which can be obtained from APHIS, for example on the APHIS website, by reference to this petition number. These descriptions are now incorporated by reference.
[00266] Extension of the Petition: reference to a previous petition for which an extension is required.
[00267] Institution: name of the entity that submits the petition.
[00268] Regulated article: the species of the plant in question.
[00269] Transgenic phenotype: the characteristic conferred to plants by the transformation event.
[00270] Event or transformation line: the name of the event or events (often also referred to as lines) for which (s) non-regulated status is requested.
[00271] APHIS Documents: Various documents published by APHIS in relation to the Petition and which can be requested by APHIS.
[00272] Additional particularly useful plants, containing unique transformation events or combinations of transformation events are indicated in the databases of various national or regional regulatory agencies (cf., for example http: // gmoinfo. Jrc.it/ gmpbrowse.aspxe http://www.agbios.com/dbase.php).
[00273] Particularly useful transgenic plants that can be treated according to the invention are plants that contain transformation events or a combination of transformation events and which are indicated, for example, in the databases for various national or regional regulatory agencies , including Event 1143-14A (cotton, insect control, not deposited, described in WO 2006/128569); Event 1143-51B (cotton, insect control, not deposited, described in WO 2006/128570); Event 1445 (cotton, herbicide tolerance, not deposited, described in US-A 2002120964 or WO 02/034946); Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, described in WO 2010/117737); Event 17314 (rice, herbicide tolerance, deposited as PTA-9844, described in WO 2010/117735); Event 281-24-236 (cotton, insect control, - herbicide tolerance, deposited as PTA-6233, described in WO 2005/103266 or US-A 2005-216969); Event 3006210-23 (cotton, insect control - herbicide tolerance, deposited as PTA-6233, described in US-A 2007-143876 or WO 2005/103266); Event 3272 (corn, quality trait, deposited as PTA9972, described in WO 2006/098952 or US-A 2006-230473); Event 40416 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-11508, described in WO 2011/075593); Event 43A47 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-11509, described in WO 2011/075595); Event 5307 (corn, insect control, deposited as ATCC PTA-9561, described in WO 2010/077816); Event ASR-368 (curved grass, herbicide tolerance, deposited as ATCC PTA-4816, described in US-A 2006-162007 or WO 2004/053062); Event B16 (maize, herbicide tolerance, not deposited, described in US-A 2003-126634); Event BPSCV127-9 (soybean, herbicide tolerance, deposited as NCIMB No. 41603, described in WO 2010/080829); Event CE43-67B (cotton, insect control, deposited as DSM ACC2724, described in USA 2009-217423 or WO2006 / 128573); Event CE44-69D (cotton, insect control, not deposited, described in US-A 2010-0024077); Event CE44-69D (cotton, insect control, not deposited, described in WO 2006/128571); Event CE46-02A (cotton, insect control, not deposited, described in WO 2006/128572); Event COT102 (cotton, insect control, not deposited, described in USA 2006-130175 or WO 2004/039986); Event COT202 (cotton, insect control, not deposited, described in US-A 2007-067868 or WO 2005/054479); Event COT203 (cotton, insect control, not deposited, described in WO 2005/054480); DAS40278 event (corn, herbicide tolerance, deposited as ATCC PTA-10244, described in WO 2011/022469); Event DAS-59122-7 (corn, insect control - tolerance to herbicides, deposited as ATCC PTA 11384, described in US-A 2006-070139); Event DAS-59132 (corn, insect control - herbicide tolerance, not deposited, described in WO 2009/100188); DAS68416 event (soybean, herbicide tolerance, deposited as ATCC PTA-10442, described in WO 2011/066384 or WO 2011/066360); Event DP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA-8296, described in US-A 2009-137395 or WO 2008/112019); Event DP-305423-1 (soybean, quality trace, not deposited, described in USA 2008-312082 or WO 2008/054747); Event DP-32138-1 (corn, hybridization system, deposited as ATCC PTA-9158, described in US-A 2009-0210970 or WO 2009/103049); Event DP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287, described in US-A 2010-0184079 or WO 2008/002872); Event EE-1 "(brinjal", insect control, not deposited, described in WO 2007/091277); Event FI117 (corn, herbicide tolerance, deposited as ATCC 209031, described in US-A 2006-059581 or WO 98/044140); Event GA21 (corn, herbicide tolerance, deposited as ATCC 209033, described in US-A 2005-086719 or WO 98/044140); Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032, described in US-A 2005-188434 or WO 98/044140); Event GHB119 (cotton, insect control - herbicide tolerance, deposited as ATCC PTA-8398, described in WO 2008/151780); Event GHB614 (cotton, herbicide tolerance, deposited as ATCC PTA-6878, described in US-A 2010-050282 or WO 2007/017186); Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030, described in US-A 2005-188434 or WO 98/044140); GM RZ13 event (sugar beet, virus resistance, deposited as NCIMB-41601, described in WO 2010/076212); Event H7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 or NCIMB 41159, described in US-A 2004-172669 or WO 2004/074492); Event JOPLIN1 (wheat, disease tolerance, not deposited, described in US-A 2008-064032); Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658, described in WO 2006/108674 or US-A 2008-320616); Event LL55 (soybean, herbicide tolerance, deposited as NCIMB 41660, described in WO 2006/108675 or US-A 2008-196127); Event LLalg cotton25 (cotton, herbicide tolerance, deposited as ATCC PTA-3343, described in WO 03/013224 or US-A 2003-097687); Event LLRICE06 (rice, herbicide tolerance, deposited as ATCC-23352, described in US 6,468,747 or WO 00/026345); Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600, described in US-A 2008-2289060 or WO 00/026356); Event LY038 (corn, quality trait, deposited as ATCC PTA-5623, described in US-A 2007-028322 or WO 2005/061720); Event MIR162 (corn, insect control, deposited as PTA-8166, described in US-A 2009-300784 or WO 2007/142840); Event MIR604 (corn, insect control, not deposited, described in US-A 2008167456 or WO 2005/103301); Event MON15985 (cotton, insect control, deposited as ATCC PTA-2516, described in US-A 2004-250317 or WO 02/100163); MON810 event (corn, insect control, not deposited, described in US-A 2002-102582); MON863 event (corn, insect control, deposited as ATCC PTA-2605, described in WO 2004/011601 or US-A 2006095986); Event MON87427 (corn, pollination control, deposited as ATCC PTA-7899, described in WO 2011/062904); Event MON87460 (corn, tolerance to stress / tension, deposited as ATCC PTA-8910, described in WO 2009/111263 or US-A 2011-0138504); Event MON87701 (soybean, insect control, deposited as ATCC PTA-8194, described in US-A 2009130071 or WO 2009/064652); Event MON87705 (soybean, trait of quality - herbicide tolerance, deposited as ATCC PTA-9241, described in US-A 2010-0080887 or WO 2010/037016); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC PTA9670, described in WO 2011/034704); Event MON87754 (soybean, quality trait, deposited as ATCC PTA-9385, described in WO 2010/024976); Event MON87769 (soybean, trace of quality, deposited as ATCC PTA-8911, described in USA 2011-0067141 or WO 2009/102873); Event MON88017 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-5582, described in US-A 2008-028482 or WO 2005/059103); Event MON88913 (cotton, herbicide tolerance, deposited as ATCC PTA-4854, described in WO 2004/072235 or US-A 2006- 059590); Event MON89034 (corn, insect control, deposited as ATCC PTA-7455, described in WO 2007/140256 or US-A 2008-260932); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC PTA-6708, described in US-A 2006-282915 or WO 2006/130436); Event MS11 (rapeseed, pollination control - herbicide tolerance, deposited as ATCC PTA850 or PTA-2485, described in WO 01/031042); Event MS8 (rapeseed, pollination control - herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or US-A 2003-188347); Event NK603 (corn, herbicide tolerance, deposited as ATCC PTA-2478, described in US-A 2007-292854); Event PE-7 (rice, insect control, not deposited, described in WO 2008/114282); Event RF3 (rapeseed, pollination control - herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or USA 2003-188347); Event RT73 (rapeseed, herbicide tolerance, not deposited, described in WO 02/036831 or US-A 2008-070260); Event T227-1 (sugar beet, herbicide tolerance, not deposited, described in WO 02/44407 or US-A 2009-265817); Event T25 (corn, herbicide tolerance, not deposited, described in US-A 2001-029014 or WO 01/051654); Event T304-40 (cotton, insect control - herbicide tolerance, deposited as ATCC PTA-8171, described in US-A 2010-077501 or WO 2008/122406); Event T342-142 (cotton, insect control, not deposited, described in WO 2006/128568); Event TC1507 (corn, insect control - herbicide tolerance, not deposited, described in US-A 2005-039226 or WO 2004/099447); Event VIP1034 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-3925., Described in WO 03/052073), Event 32316 (corn, insect control - herbicide tolerance, deposited as PTA-11507, described in WO 2011/084632), Event 4114 (corn, insect control - herbicide tolerance, deposited as PTA-11506, described in WO 2011/084621).
[00274] Very particularly useful transgenic plants that can be treated according to the invention are plants that contain transformation events or a combination of transformation events and that are indicated, for example, in the databases for various national and regional regulatory agencies , including Event BPS-CV127-9 (soybean, herbicide tolerance, deposited as NCIMB No. 41603, described in WO 2010/080829); DAS68416 event (soybean, herbicide tolerance, deposited as ATCC PTA10442, described in WO 2011/066384 or WO 2011/066360); Event DP-3560435 (soybean, herbicide tolerance, deposited as ATCC PTA-8287, described in US-A 2010-0184079 or WO 2008/002872); Event EE-1 ("brinjal", insect control, not deposited, described in WO 2007/091277); Event FI117 (corn, herbicide tolerance, deposited as ATCC 209031, described in US-A 2006059581 or WO 98/044140); Event GA21 (corn, herbicide tolerance, deposited as ATCC 209033, described in US-A 2005-086719 or WO 98/044140), Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658, described in WO 2006/108674 or US -A 2008-320616); Event LL55 (soybean, herbicide tolerance, deposited as NCIMB 41660, described in WO 2006/108675 or US-A 2008-196127); MON87701 event (soybean, insect control, deposited as ATCC PTA-8194, described in US-A 2009-130071 or WO 2009/064652); Event MON87705 (soybean, trait of quality - herbicide tolerance, deposited as ATCC PTA-9241, described in US-A 2010-0080887 or WO 2010/037016); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC PTA9670, described in WO 2011/034704); Event MON87754 (soybean, quality trait, deposited as ATCC PTA-9385, described in WO 2010/024976); Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911, described in US-A 2011-0067141 or WO 2009/102873); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC PTA-6708, described in US-A 2006-282915 or WO 2006/130436).
[00275] Transgenic soy is particularly preferred. Application Fees and Time
[00276] When using the inventive mixtures or compositions as fungicides, application rates can vary within relatively wide limits, depending on the type of application. The application rate of the active ingredients of the invention is in the case of treatment of plant parts, for example, leaves: from 0.1 to 10,000 g / ha, preferably from 10 to 1000 g / ha, more preferably from 10 to 800 g / ha, even more preferably from 50 to 300 g / ha (in the case of application by irrigation or immersion, it is still possible to reduce the application rate, especially when inert substances such as rock wool or perlite are used.
[00277] In the case of seed treatment: from 2 to 200 g per 100 kg of seed, preferably from 3 to 150 g per 100 kg of seed, more preferably from 2.5 to 25 g per 100 kg of seed, and even more preferably 2.5 to 12.5 g per 100 kg of seed; in the case of soil treatment: from 0.1 to 10,000 g / ha, preferably from 1 to 5000 g / ha.
[00278] These application rates are for example only and are not limiting for the purpose of this invention.
[00279] The mixtures or compositions of the invention can therefore be used to protect plants from attack by pathogens mentioned above for a certain period of time after treatment. The period for which protection is provided normally extends from 1 to 28 days, preferably from 1 to 14 days, more preferably from 1 to 10 days, even more preferably from 1 to 7 days, after treating the plants with the mixtures or compositions, or up to 200 days after seed treatment.
[00280] The treatment method according to the invention also presents the use or application of compounds (I) and (II) and / or (III) simultaneously, separately or sequentially. If single active ingredients are applied in a sequential manner, that is, at different times, they are applied one after the other within a reasonably short period of time, such as a few hours or days. Preferably the order of application of compounds (A) and (B) and / or (C) is not essential in terms of the applicability of the present invention.
[00281] The indicated plants can be treated in a particularly advantageous manner according to the invention with the mixtures or compositions of the invention. The above preferred ranges for active ingredients or compositions also apply to the treatment of these plants. Particular attention is paid to the treatment of plants with the compounds or compositions specifically mentioned in this text. Examples
[00282] The advanced fungicidal activity of the combinations of the active compound according to the invention is evident from the following examples While the individual active compounds exhibit weaknesses with respect to the fungicidal activity, the combinations show an activity that exceeds a simple addition of the activities .
[00283] A synergistic effect of fungicides is always present when the fungicidal activity of the active compound combinations exceeds the total activities of the active compounds when applied individually. The predicted activity for a given combination of two active compounds can be calculated as follows (see Colby ("Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967, 15, 20-22):
[00284] If
[00285] X is the effectiveness when the active compound A is used at an application rate of m ppm (or g / ha),
[00286] Y is the effectiveness when the active compound B is used at an application rate of n ppm (or g / ha),
[00287] Z is the effectiveness when the active compound B is used at an application rate of r ppm (or g / ha),
[00288] E1 is the effectiveness when the active compounds A and B are applied at rates of application of m and n ppm (or g / ha) respectively and
[00289] E2 is the effectiveness when the active compounds A and B and C are applied at rates of application of m, ner ppm (or g / ha) respectively and then
and for a ternary mixture:

[00290] The degree of effectiveness expressed in% is obtained. 0% means an efficacy that corresponds to that of the control, while an efficacy of 100% means that no disease was observed.
[00291] If the actual fungicidal activity exceeds the calculated value, the activity of the combination is super additive, that is, there is a synergistic effect. In this case, the effectiveness that was actually observed must be greater than the expected effectiveness value (E), calculated from the Formula mentioned.
[00292] Another way to demonstrate the synergistic effect is the Tammes method (see "Isoboles, the graphic representation of synergism in pesticides" in Neth. J. Plant Path., 1964, 70, 73-80).
[00293] The invention is illustrated by the following example. However, the invention is not limited to the example. Example Puccinia triticina (wheat) / preventive test Solvent: 49 parts by weight of N, N-dimethylacetamide
[00294] Emulsifier: 1 part by weight of alkylaryl polyglycolic ether To produce a suitable formulation of the active compound, 1 part by weight of active compound or combination of the active compound is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water until you reach the desired concentration.
[00295] To test the preventive activity, young plants are sprayed with the preparation of the active compound or combination of the active compound at the indicated application rate.
[00296] After the sprayed layer is dried, the plants are sprayed with a spore suspension of Puccinia triticina. The plants are kept for 48 hours In an incubator, at approximately 20 ° C and a relative humidity of approximately 100%.
[00297] The plants are placed in a greenhouse at a temperature of approximately 20 ° C and a relative humidity of approximately 80%.
[00298] This test is evaluated 8 days after inoculation. 0% means an efficacy that corresponds to that of the control without treatment, while a 100% efficacy means that no disease was observed.
[00299] The following table clearly shows that the observed activity of the combination of the active compound according to the invention is greater than the calculated activity, that is, a synergistic effect is present. Puccinia triticina (wheat) / preventive test table
* enc = activity found ** calc. = activity calculated using the Colby Formula

权利要求:
Claims (7)
[0001]
1. Fungicidal composition, characterized by the fact that it comprises: (i) (I-1) 3- (difluoromethyl) -1-methyl-N (1,1,3-trimethyl-2,3-dihydro-1H-inden- 4yl) -H-pyrazol-4-carboxamide, (2.23) protioconazole and (3.2) azoxystrobin, or (3.14) pyraclostrobin, or (3.15) trifloxystrobin, in a weight ratio of (3: 2: 1); or (ii) (I-1 (R)) 3- (difluoromethyl) -1-methyl-N - [(3R) -1,1,3-trimethyl-2,3-dihydro-1H-inden-4yl] - 1H-pyrazol-4-carboxamide, (2.23) protioconazole and (3.15) trifloxystrobin, with the weight ratio between each of the compounds (I-1 (R)), (2.23) and (3.15) being, independently of the another, from (5: 1) to (1: 5).
[0002]
2. Method for controlling one or more harmful microorganisms, characterized by the fact that it comprises contacting said harmful microorganisms and / or their habitat with a composition, as defined in claim 1, excluding treatment in humans and / or animals.
[0003]
3. Method, according to claim 2, characterized by the fact that the microorganism comprises phytopathogenic fungi.
[0004]
4. Method, according to claim 3, characterized by the fact that one or more microorganisms are controlled in wheat or soy.
[0005]
5. Seed treatment method, characterized by the fact that it comprises coating said seeds with a composition, as defined in claim 1.
[0006]
6. Process for preparing a composition, characterized by the fact that it comprises mixing a composition, as defined in claim 1, with an extender, a surfactant, or a combination thereof.
[0007]
7. Seed resistant to harmful microorganisms, characterized by the fact that it comprises a seed coated with a composition, as defined in claim 1.

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同族专利:

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公开号 | 公开日

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UA116117C2|2018-02-12|

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AR118341A2|2021-09-29|

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CA2892699A1|2014-06-05|

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EA201500582A1|2016-01-29|

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MX2015006327A|2015-10-05|

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WO2014082950A1|2014-06-05|

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US20180098540A1|2018-04-12|

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EP2925134B1|2019-12-25|

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US20150313223A1|2015-11-05|

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CN104981162B|2017-11-28|

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US20200138026A1|2020-05-07|

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EP2925134A1|2015-10-07|

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CN104981162A|2015-10-14|

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US10575522B2|2020-03-03|

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US9943082B2|2018-04-17|

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JP2016504294A|2016-02-12|

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BR122020019349B1|2021-05-11|

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法律状态:
2018-03-06| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2018-03-13| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2018-03-20| B06I| Publication of requirement cancelled [chapter 6.9 patent gazette]|Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |

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2019-05-14| B06T| Formal requirements before examination [chapter 6.20 patent gazette]|

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2019-10-01| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|

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2020-02-04| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|

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2020-06-09| B06I| Publication of requirement cancelled [chapter 6.9 patent gazette]|Free format text: ANULADA A PUBLICACAO CODIGO 6.1 NA RPI NO 2561 DE 04/02/2020 POR TER SIDO INDEVIDA. |

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2020-07-07| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|

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2020-11-24| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2021-01-12| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/11/2013, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

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EP12195171|2012-11-30|

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EP12195171.9|2012-11-30|

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PCT/EP2013/074573|WO2014082950A1|2012-11-30|2013-11-25|Ternary fungicidal mixtures|BR122020019349-2A| BR122020019349B1|2012-11-30|2013-11-25|composition, its preparation process, method for controlling one or more harmful microorganisms, seed resistant to harmful microorganisms and its method of treatment|